Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total (n = 80) | Low Adherence to MD (n = 39) | High Adherence to MD (n = 41) | p-Value | |
---|---|---|---|---|
Age (years) Male/female (%) BMI (Kg/m2) | 67.5 ± 11.8 | 66.1 ± 12.5 | 68.9 ± 11.2 | 0.297 |
35.0/65.0 | 66.7/33.3 | 63.4/36.6 | 0.764 | |
28.0 ± 3.9 | 28.0 ± 3.7 | 28.1 ± 4.2 | 0.891 | |
Glucose (mg/dL) Total cholesterol (mg/dL) | 116.6 ± 52.3 | 116.3 ± 40.6 | 116.9 ± 30.2 | 0.943 |
180.5 ± 39.1 | 181.3 ± 36.0 | 179.6 ± 42.2 | 0.850 | |
HDLc (mg/dL) LDLc (mg/dL) | 43.2 ± 10.8 | 40.8 ± 9.8 | 45.5 ± 11.4 | 0.048 |
114.5 ± 34.7 | 115.7 ± 33.6 | 113.3 ± 36.2 | 0.762 | |
Triglycerides (mg/dL) | 108.5 (83.3; 141.0) | 109.0 (83.0; 150.0) | 106.0 (81.5; 133.5) | 0.185 |
Uric acid (mg/dL) | 5.3 ± 1.7 | 5.1 ± 1.8 | 5.5 ± 1.6 | 0.282 |
Albumin (g/dL) | 4.2 ± 0.5 | 4.2 ± 0.3 | 4.2 ± 0.6 | 0.505 |
CEA (ng/mL) | 2.9 (1.7; 6.0) | 3.5 (1.9; 11.6) | 2.0 (1.6; 4.7) | 0.081 |
CA 19.9 (IU/mL) | 13.3 (6.3; 26.4) | 15.5 (7.9; 32.4) | 9.4 (5.7; 24.0) | 0.164 |
(%) | Low Adherence to MD | High Adherence to MD | p-Value |
---|---|---|---|
Tumor diameter <6 (n = 67) ≥6 (n = 9) | 0.923 | ||
47.8 | 52.2 | ||
44.4 | 55.5 | ||
WHO histological grade | 0.031 | ||
Low (n = 69) | 43.5 | 56.5 | |
High (n = 10) | 80.0 | 20.0 | |
Co-existence of adenomas | 0.034 | ||
No (n = 44) | 37.2 | 62.8 | |
Yes (n = 36) | 61.1 | 38.9 | |
Presence of diverticulosis | 0.203 | ||
No (n = 65) | 51.6 | 48.4 | |
Yes (n = 15) | 33.3 | 66.7 | |
Tumor localization | 0.137 | ||
Right colon (n = 29) | 34.5 | 65.5 | |
Left colon (n = 23) | 60.9 | 39.1 | |
Rectum (n = 28) | 53.6 | 46.4 | |
Synchronous tumors | 0.949 | ||
No (n = 74) | 48.6 | 51.4 | |
Yes (n = 6) | 50.0 | 50.0 | |
Complications * | 0.270 | ||
No (n = 61) Yes (n = 15) | 49.2 | 50.8 | |
33.3 | 66.7 | ||
Tumor recurrence | 0.926 | ||
No (n = 74) | 46.7 | 53.3 | |
Yes (n = 2) | 50.0 | 50.0 | |
Tumor stage | 0.220 | ||
0 (n = 45) | 47.4 | 61.0 | |
1 (n = 26) | 36.8 | 34.1 | |
2 (n = 9) | 15.8 | 4.9 |
Adherence to MD Score (MEDAS) | CEA | CA 19.9 | |
---|---|---|---|
CAT serum GPX serum GSH serum | r = 0.004; p = 0.974 | r = −0.398; p < 0.001 | r = −0.462; p < 0.001 |
r = 0.225; p = 0.045 | r = −0.352; p = 0.001 | r = −0.311; p = 0.005 | |
r = 0.141; p = 0.211 | r = −0.309; p = 0.005 | r = −0.256; p = 0.022 | |
GSSG serum GSSG/GSH serum | r = −0.118; p = 0.299 | r = 0.461; p < 0.001 | r = −0.459; p < 0.001 |
r = −0.114; p = 0.313 | r = 0.429; p < 0.001 | r = 0.349; p = 0.002 | |
8-oxodG urine F2-IsoPs urine | r = −0.163; p = 0.148 | r = 0.291; p = 0.009 | r = 0.170; p = 0.132 |
r = 0.008; p = 0.942 | r = 0.271; p = 0.015 | r = 0.367; p = 0.001 |
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Acevedo-León, D.; Gómez-Abril, S.Á.; Monzó-Beltrán, L.; Estañ-Capell, N.; Arroyo-Montañés, R.; Bañuls, C.; Salas-Salvadó, J.; Sáez, G. Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients. Antioxidants 2022, 11, 499. https://doi.org/10.3390/antiox11030499
Acevedo-León D, Gómez-Abril SÁ, Monzó-Beltrán L, Estañ-Capell N, Arroyo-Montañés R, Bañuls C, Salas-Salvadó J, Sáez G. Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients. Antioxidants. 2022; 11(3):499. https://doi.org/10.3390/antiox11030499
Chicago/Turabian StyleAcevedo-León, Delia, Segundo Ángel Gómez-Abril, Lidia Monzó-Beltrán, Nuria Estañ-Capell, Rafael Arroyo-Montañés, Celia Bañuls, Jordi Salas-Salvadó, and Guillermo Sáez. 2022. "Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients" Antioxidants 11, no. 3: 499. https://doi.org/10.3390/antiox11030499
APA StyleAcevedo-León, D., Gómez-Abril, S. Á., Monzó-Beltrán, L., Estañ-Capell, N., Arroyo-Montañés, R., Bañuls, C., Salas-Salvadó, J., & Sáez, G. (2022). Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients. Antioxidants, 11(3), 499. https://doi.org/10.3390/antiox11030499