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Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland
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Academic Editor: Eugenio Barone
Antioxidants 2021, 10(9), 1439; https://doi.org/10.3390/antiox10091439
Received: 29 July 2021 / Revised: 1 September 2021 / Accepted: 6 September 2021 / Published: 9 September 2021
There is a growing body of scientific research showing the link between depression and dementia in Alzheimer’s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron. View Full-Text
Keywords: chronic stress; oxidative stress; depression; Alzheimer’s disease; antioxidants chronic stress; oxidative stress; depression; Alzheimer’s disease; antioxidants
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MDPI and ACS Style

Juszczyk, G.; Mikulska, J.; Kasperek, K.; Pietrzak, D.; Mrozek, W.; Herbet, M. Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment. Antioxidants 2021, 10, 1439. https://doi.org/10.3390/antiox10091439

AMA Style

Juszczyk G, Mikulska J, Kasperek K, Pietrzak D, Mrozek W, Herbet M. Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment. Antioxidants. 2021; 10(9):1439. https://doi.org/10.3390/antiox10091439

Chicago/Turabian Style

Juszczyk, Gabriela, Joanna Mikulska, Kamila Kasperek, Diana Pietrzak, Weronika Mrozek, and Mariola Herbet. 2021. "Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment" Antioxidants 10, no. 9: 1439. https://doi.org/10.3390/antiox10091439

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