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Article

Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation

1
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
2
Department of Neuroscience, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
3
Department of Otolaryngology Head and Neck Surgery, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Andreas Von Knethen
Antioxidants 2021, 10(8), 1188; https://doi.org/10.3390/antiox10081188
Received: 13 July 2021 / Revised: 21 July 2021 / Accepted: 22 July 2021 / Published: 26 July 2021
The cross-talk between oxidative stress and inflammation seems to play a key role in noise-induced hearing loss. Several studies have addressed the role of PPAR receptors in mediating antioxidant and anti-inflammatory effects and, although its protective activity has been demonstrated in several tissues, less is known about how PPARs could be involved in cochlear dysfunction induced by noise exposure. In this study, we used an in vivo model of noise-induced hearing loss to investigate how oxidative stress and inflammation participate in cochlear dysfunction through PPAR signaling pathways. Specifically, we found a progressive decrease in PPAR expression in the cochlea after acoustic trauma, paralleled by an increase in oxidative stress and inflammation. By comparing an antioxidant (Q-ter) and an anti-inflammatory (Anakinra) treatment, we demonstrated that oxidative stress is the primary element of damage in noise-induced cochlear injury and that increased inflammation can be considered a consequence of PPAR down-regulation induced by ROS production. Indeed, by decreasing oxidative stress, PPARs returned to control values, reactivating the negative control on inflammation in a feedback loop. View Full-Text
Keywords: acoustic trauma; cochlea; NF-κB; ROS; IL-1β; Q-ter; Anakinra acoustic trauma; cochlea; NF-κB; ROS; IL-1β; Q-ter; Anakinra
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MDPI and ACS Style

Paciello, F.; Pisani, A.; Rolesi, R.; Escarrat, V.; Galli, J.; Paludetti, G.; Grassi, C.; Troiani, D.; Fetoni, A.R. Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation. Antioxidants 2021, 10, 1188. https://doi.org/10.3390/antiox10081188

AMA Style

Paciello F, Pisani A, Rolesi R, Escarrat V, Galli J, Paludetti G, Grassi C, Troiani D, Fetoni AR. Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation. Antioxidants. 2021; 10(8):1188. https://doi.org/10.3390/antiox10081188

Chicago/Turabian Style

Paciello, Fabiola, Anna Pisani, Rolando Rolesi, Vincent Escarrat, Jacopo Galli, Gaetano Paludetti, Claudio Grassi, Diana Troiani, and Anna R. Fetoni. 2021. "Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation" Antioxidants 10, no. 8: 1188. https://doi.org/10.3390/antiox10081188

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