Next Article in Journal
Protective Effects of Maclurin against Benzo[a]pyrene via Aryl Hydrocarbon Receptor and Nuclear Factor Erythroid 2-Related Factor 2 Targeting
Next Article in Special Issue
Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea
Previous Article in Journal
Variation of the Polyphenolic Composition and Antioxidant Capacity of Freshly Prepared Pomegranate Leaf Infusions over One-Day Storage
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Antioxidants
Volume 10
Issue 8
10.3390/antiox10081188
antioxidants-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation

by
Fabiola Paciello
1,2,
Anna Pisani
3,
Rolando Rolesi
3,
Vincent Escarrat
3,
Jacopo Galli
1,3,
Gaetano Paludetti
1,3,
Claudio Grassi
1,2,*,
Diana Troiani
2 and
Anna Rita Fetoni
1,3,*
1
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
2
Department of Neuroscience, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
3
Department of Otolaryngology Head and Neck Surgery, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Andreas Von Knethen
Antioxidants 2021, 10(8), 1188; https://doi.org/10.3390/antiox10081188
Received: 13 July 2021 / Revised: 21 July 2021 / Accepted: 22 July 2021 / Published: 26 July 2021
(This article belongs to the Special Issue Oxidative Stress and Inflammation in Deafness: Current and Future Therapy)
View Full-Text Download PDF
Browse Figures

Abstract

The cross-talk between oxidative stress and inflammation seems to play a key role in noise-induced hearing loss. Several studies have addressed the role of PPAR receptors in mediating antioxidant and anti-inflammatory effects and, although its protective activity has been demonstrated in several tissues, less is known about how PPARs could be involved in cochlear dysfunction induced by noise exposure. In this study, we used an in vivo model of noise-induced hearing loss to investigate how oxidative stress and inflammation participate in cochlear dysfunction through PPAR signaling pathways. Specifically, we found a progressive decrease in PPAR expression in the cochlea after acoustic trauma, paralleled by an increase in oxidative stress and inflammation. By comparing an antioxidant (Q-ter) and an anti-inflammatory (Anakinra) treatment, we demonstrated that oxidative stress is the primary element of damage in noise-induced cochlear injury and that increased inflammation can be considered a consequence of PPAR down-regulation induced by ROS production. Indeed, by decreasing oxidative stress, PPARs returned to control values, reactivating the negative control on inflammation in a feedback loop. View Full-Text
Keywords: acoustic trauma; cochlea; NF-κB; ROS; IL-1β; Q-ter; Anakinra acoustic trauma; cochlea; NF-κB; ROS; IL-1β; Q-ter; Anakinra
►▼ Show Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Paciello, F.; Pisani, A.; Rolesi, R.; Escarrat, V.; Galli, J.; Paludetti, G.; Grassi, C.; Troiani, D.; Fetoni, A.R. Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation. Antioxidants 2021, 10, 1188. https://doi.org/10.3390/antiox10081188

AMA Style

Paciello F, Pisani A, Rolesi R, Escarrat V, Galli J, Paludetti G, Grassi C, Troiani D, Fetoni AR. Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation. Antioxidants. 2021; 10(8):1188. https://doi.org/10.3390/antiox10081188

Chicago/Turabian Style

Paciello, Fabiola, Anna Pisani, Rolando Rolesi, Vincent Escarrat, Jacopo Galli, Gaetano Paludetti, Claudio Grassi, Diana Troiani, and Anna R. Fetoni. 2021. "Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation" Antioxidants 10, no. 8: 1188. https://doi.org/10.3390/antiox10081188

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop