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Review

Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review

1
Department of Dermatology, Jagiellonian University Medical College, 31-501 Cracow, Poland
2
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland
3
Student Scientific Group, Department of Dermatology, Jagiellonian University Medical College, 31-501 Cracow, Poland
4
Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 31-126 Cracow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Gaia Favero
Antioxidants 2021, 10(8), 1179; https://doi.org/10.3390/antiox10081179
Received: 10 June 2021 / Revised: 16 July 2021 / Accepted: 22 July 2021 / Published: 24 July 2021
(This article belongs to the Special Issue Role of Antioxidant Molecules and Melatonin in Cellular Protection)
Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possesses strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with a focus on the antioxidant and immunomodulatory effects of MT. View Full-Text
Keywords: atopic dermatitis; melatonin; sleep disturbances atopic dermatitis; melatonin; sleep disturbances
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MDPI and ACS Style

Jaworek, A.K.; Szepietowski, J.C.; Hałubiec, P.; Wojas-Pelc, A.; Jaworek, J. Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review. Antioxidants 2021, 10, 1179. https://doi.org/10.3390/antiox10081179

AMA Style

Jaworek AK, Szepietowski JC, Hałubiec P, Wojas-Pelc A, Jaworek J. Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review. Antioxidants. 2021; 10(8):1179. https://doi.org/10.3390/antiox10081179

Chicago/Turabian Style

Jaworek, Andrzej K., Jacek C. Szepietowski, Przemysław Hałubiec, Anna Wojas-Pelc, and Jolanta Jaworek. 2021. "Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review" Antioxidants 10, no. 8: 1179. https://doi.org/10.3390/antiox10081179

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