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Protein Lipoxidation: Basic Concepts and Emerging Roles

Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (C.S.I.C.), 28040 Madrid, Spain
College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Author to whom correspondence should be addressed.
Academic Editor: Giuseppina Barrera
Antioxidants 2021, 10(2), 295;
Received: 25 January 2021 / Revised: 9 February 2021 / Accepted: 10 February 2021 / Published: 16 February 2021
Protein lipoxidation is a non-enzymatic post-translational modification that consists of the covalent addition of reactive lipid species to proteins. This occurs under basal conditions but increases in situations associated with oxidative stress. Protein targets for lipoxidation include metabolic and signalling enzymes, cytoskeletal proteins, and transcription factors, among others. There is strong evidence for the involvement of protein lipoxidation in disease, including atherosclerosis, neurodegeneration, and cancer. Nevertheless, the involvement of lipoxidation in cellular regulatory mechanisms is less understood. Here we review basic aspects of protein lipoxidation and discuss several features that could support its role in cell signalling, including its selectivity, reversibility, and possibilities for regulation at the levels of the generation and/or detoxification of reactive lipids. Moreover, given the great structural variety of electrophilic lipid species, protein lipoxidation can contribute to the generation of multiple structurally and functionally diverse protein species. Finally, the nature of the lipoxidised proteins and residues provides a frameshift for a complex interplay with other post-translational modifications, including redox and redox-regulated modifications, such as oxidative modifications and phosphorylation, thus strengthening the importance of detailed knowledge of this process. View Full-Text
Keywords: lipoxidation; electrophilic lipids; oxidative stress; cell signalling; regulation; selectivity; post-translational modifications lipoxidation; electrophilic lipids; oxidative stress; cell signalling; regulation; selectivity; post-translational modifications
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MDPI and ACS Style

Viedma-Poyatos, Á.; González-Jiménez, P.; Langlois, O.; Company-Marín, I.; Spickett, C.M.; Pérez-Sala, D. Protein Lipoxidation: Basic Concepts and Emerging Roles. Antioxidants 2021, 10, 295.

AMA Style

Viedma-Poyatos Á, González-Jiménez P, Langlois O, Company-Marín I, Spickett CM, Pérez-Sala D. Protein Lipoxidation: Basic Concepts and Emerging Roles. Antioxidants. 2021; 10(2):295.

Chicago/Turabian Style

Viedma-Poyatos, Álvaro, Patricia González-Jiménez, Ophélie Langlois, Idoia Company-Marín, Corinne M. Spickett, and Dolores Pérez-Sala. 2021. "Protein Lipoxidation: Basic Concepts and Emerging Roles" Antioxidants 10, no. 2: 295.

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