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Review

Current Status and Future Perspectives on Therapeutic Potential of Apigenin: Focus on Metabolic-Syndrome-Dependent Organ Dysfunction

1
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
2
Laboratory of Cellular and Molecular Cardiovascular Physiology, Department of Biology, Ecology and Earth Sciences (Di.B.E.S.T.), University of Calabria, 87036 Rende, Italy
3
College of Pharmaceutical Sciences, Soochow University, Suzhou 221400, China
4
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA
5
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
6
National Institute of Cardiovascular Research I.N.R.C., 40126 Bologna, Italy
7
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao 999078, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Małgorzata Elżbieta Zujko and Anna Maria Witkowska
Antioxidants 2021, 10(10), 1643; https://doi.org/10.3390/antiox10101643
Received: 20 September 2021 / Revised: 13 October 2021 / Accepted: 15 October 2021 / Published: 19 October 2021
(This article belongs to the Special Issue Dietary Antioxidants and Chronic Diseases)
Metabolic syndrome and its associated disorders such as obesity, insulin resistance, atherosclerosis and type 2 diabetes mellitus are globally prevalent. Different molecules showing therapeutic potential are currently available for the management of metabolic syndrome, although their efficacy has often been compromised by their poor bioavailability and side effects. Studies have been carried out on medicinal plant extracts for the treatment and prevention of metabolic syndrome. In this regard, isolated pure compounds have shown promising efficacy for the management of metabolic syndrome, both in preclinical and clinical settings. Apigenin, a natural bioactive flavonoid widely present in medicinal plants, functional foods, vegetables and fruits, exerts protective effects in models of neurological disorders and cardiovascular diseases and most of these effects are attributed to its antioxidant action. Various preclinical and clinical studies carried out so far show a protective effect of apigenin against metabolic syndrome. Herein, we provide a comprehensive review on both in vitro and in vivo evidence related to the promising antioxidant role of apigenin in cardioprotection, neuroprotection and renoprotection, and to its beneficial action in metabolic-syndrome-dependent organ dysfunction. We also provide evidence on the potential of apigenin in the prevention and/or treatment of metabolic syndrome, analysing the potential and limitation of its therapeutic use. View Full-Text
Keywords: apigenin; antioxidants; flavonoids; intracellular signalling; metabolic syndrome apigenin; antioxidants; flavonoids; intracellular signalling; metabolic syndrome
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MDPI and ACS Style

Alam, W.; Rocca, C.; Khan, H.; Hussain, Y.; Aschner, M.; De Bartolo, A.; Amodio, N.; Angelone, T.; Cheang, W.S. Current Status and Future Perspectives on Therapeutic Potential of Apigenin: Focus on Metabolic-Syndrome-Dependent Organ Dysfunction. Antioxidants 2021, 10, 1643. https://doi.org/10.3390/antiox10101643

AMA Style

Alam W, Rocca C, Khan H, Hussain Y, Aschner M, De Bartolo A, Amodio N, Angelone T, Cheang WS. Current Status and Future Perspectives on Therapeutic Potential of Apigenin: Focus on Metabolic-Syndrome-Dependent Organ Dysfunction. Antioxidants. 2021; 10(10):1643. https://doi.org/10.3390/antiox10101643

Chicago/Turabian Style

Alam, Waqas, Carmine Rocca, Haroon Khan, Yaseen Hussain, Michael Aschner, Anna De Bartolo, Nicola Amodio, Tommaso Angelone, and Wai S. Cheang 2021. "Current Status and Future Perspectives on Therapeutic Potential of Apigenin: Focus on Metabolic-Syndrome-Dependent Organ Dysfunction" Antioxidants 10, no. 10: 1643. https://doi.org/10.3390/antiox10101643

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