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Article

Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers

1
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
2
Vanderbilt University Medical Center, Division of Clinical Pharmacology, Nashville, TN 37232, USA
3
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, NC 27709, USA
4
Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30602, USA
5
UPR Medical Sciences Campus, University of Puerto Rico Graduate School of Public Health, San Juan, PR 00921, USA
6
College of Engineering, Northeastern University, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(1), 114; https://doi.org/10.3390/antiox10010114
Received: 18 December 2020 / Revised: 11 January 2021 / Accepted: 12 January 2021 / Published: 15 January 2021
Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal sex. In our analysis of 215 women from the PROTECT birth cohort study, we measured 14 essential and non-essential metals in urine samples at three time points during pregnancy. The oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α) and its metabolite 2,3-dinor-5,6-dihydro-15-15-F2t-IsoP, as well as prostaglandin F2α (PGF2α), were also measured in the same urine samples. Using linear mixed models, we examined the main effects of metals on markers of oxidative stress as well as the visit-specific and fetal sex-specific effects. After adjustment for covariates, we found that a few urinary metal concentrations, most notably cesium (Cs) and copper (Cu), were associated with higher 8-iso-PGF2α with effect estimates ranging from 7.3 to 14.9% for each interquartile range, increase in the metal concentration. The effect estimates were generally in the same direction at the three visits and a few were significant only among women carrying a male fetus. Our data show that higher urinary metal concentrations were associated with elevated biomarkers of oxidative stress. Our results also indicate a potential vulnerability of women carrying a male fetus. View Full-Text
Keywords: metals; isoprostane; biomarkers; oxidative stress; Puerto Rico metals; isoprostane; biomarkers; oxidative stress; Puerto Rico
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MDPI and ACS Style

Ashrap, P.; Watkins, D.J.; Milne, G.L.; Ferguson, K.K.; Loch-Caruso, R.; Fernandez, J.; Rosario, Z.; Vélez-Vega, C.M.; Alshawabkeh, A.; Cordero, J.F.; Meeker, J.D. Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers. Antioxidants 2021, 10, 114. https://doi.org/10.3390/antiox10010114

AMA Style

Ashrap P, Watkins DJ, Milne GL, Ferguson KK, Loch-Caruso R, Fernandez J, Rosario Z, Vélez-Vega CM, Alshawabkeh A, Cordero JF, Meeker JD. Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers. Antioxidants. 2021; 10(1):114. https://doi.org/10.3390/antiox10010114

Chicago/Turabian Style

Ashrap, Pahriya, Deborah J. Watkins, Ginger L. Milne, Kelly K. Ferguson, Rita Loch-Caruso, Jennifer Fernandez, Zaira Rosario, Carmen M. Vélez-Vega, Akram Alshawabkeh, José F. Cordero, and John D. Meeker. 2021. "Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers" Antioxidants 10, no. 1: 114. https://doi.org/10.3390/antiox10010114

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