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SNP Array in Hematopoietic Neoplasms: A Review

Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Author to whom correspondence should be addressed.
Academic Editor: Stefania Bortoluzzi
Microarrays 2016, 5(1), 1;
Received: 31 July 2015 / Revised: 13 November 2015 / Accepted: 14 December 2015 / Published: 22 December 2015
(This article belongs to the Special Issue SNP Array)
Cytogenetic analysis is essential for the diagnosis and prognosis of hematopoietic neoplasms in current clinical practice. Many hematopoietic malignancies are characterized by structural chromosomal abnormalities such as specific translocations, inversions, deletions and/or numerical abnormalities that can be identified by karyotype analysis or fluorescence in situ hybridization (FISH) studies. Single nucleotide polymorphism (SNP) arrays offer high-resolution identification of copy number variants (CNVs) and acquired copy-neutral loss of heterozygosity (LOH)/uniparental disomy (UPD) that are usually not identifiable by conventional cytogenetic analysis and FISH studies. As a result, SNP arrays have been increasingly applied to hematopoietic neoplasms to search for clinically-significant genetic abnormalities. A large numbers of CNVs and UPDs have been identified in a variety of hematopoietic neoplasms. CNVs detected by SNP array in some hematopoietic neoplasms are of prognostic significance. A few specific genes in the affected regions have been implicated in the pathogenesis and may be the targets for specific therapeutic agents in the future. In this review, we summarize the current findings of application of SNP arrays in a variety of hematopoietic malignancies with an emphasis on the clinically significant genetic variants. View Full-Text
Keywords: SNP array; hematopoietic; myelodysplastic syndrome; leukemia; lymphoma SNP array; hematopoietic; myelodysplastic syndrome; leukemia; lymphoma
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Song, J.; Shao, H. SNP Array in Hematopoietic Neoplasms: A Review. Microarrays 2016, 5, 1.

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