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Protein Microarrays with Novel Microfluidic Methods: Current Advances

Biomedical Diagnostics Institute, Dublin City University, Glasnevin, Dublin-9, Ireland
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Present Address: Faculty of mechanical Engineering, Technion-Israel Institute of Technology, Haifa-32000, Israel.
Microarrays 2014, 3(3), 180-202; https://doi.org/10.3390/microarrays3030180
Received: 30 April 2014 / Revised: 10 June 2014 / Accepted: 16 June 2014 / Published: 1 July 2014
Microfluidic-based micromosaic technology has allowed the pattering of recognition elements in restricted micrometer scale areas with high precision. This controlled patterning enabled the development of highly multiplexed arrays multiple analyte detection. This arraying technology was first introduced in the beginning of 2001 and holds tremendous potential to revolutionize microarray development and analyte detection. Later, several microfluidic methods were developed for microarray application. In this review we discuss these novel methods and approaches which leverage the property of microfluidic technologies to significantly improve various physical aspects of microarray technology, such as enhanced imprinting homogeneity, stability of the immobilized biomolecules, decreasing assay times, and reduction of the costs and of the bulky instrumentation. View Full-Text
Keywords: microarray; micromosaic; microfluidic networks; centrifugal arrays; microbeads microarray; micromosaic; microfluidic networks; centrifugal arrays; microbeads
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Dixit, C.K.; Aguirre, G.R. Protein Microarrays with Novel Microfluidic Methods: Current Advances. Microarrays 2014, 3, 180-202.

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