Microarrays, Volume 2, Issue 4

December 2013 - 3 articles

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Articles (3)

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Review

11 Citations

7,761 Views

22 Pages

Lung Cancer Gene Signatures and Clinical Perspectives

Ruprecht Kuner

Microarrays2013, 2(4), 318-339;https://doi.org/10.3390/microarrays2040318

13 December 2013

Microarrays have been used for more than two decades in preclinical research. The tumor transcriptional profiles were analyzed to select cancer-associated genes for in-deep functional characterization, to stratify tumor subgroups according to the hi...

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Review

8 Citations

8,568 Views

14 Pages

Chromosomal Microarrays in Prenatal Diagnosis: Time for a Change of Policy?

Peter Miny,
Friedel Wenzel,
Sevgi Tercanli and
Isabel Filges

Microarrays2013, 2(4), 304-317;https://doi.org/10.3390/microarrays2040304

5 December 2013

Microarrays have replaced conventional karyotyping as a first-tier test for unbalanced chromosome anomalies in postnatal cytogenetics mainly due to their unprecedented resolution facilitating the detection of submicroscopic copy number changes at a r...

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Article

6 Citations

8,065 Views

20 Pages

Copy Number Studies in Noisy Samples

Philip Ginsbach,
Bowang Chen,
Yanxiang Jiang,
Stefan T. Engelter and
Caspar Grond-Ginsbach

Microarrays2013, 2(4), 284-303;https://doi.org/10.3390/microarrays2040284

6 November 2013

System noise was analyzed in 77 Affymetrix 6.0 samples from a previous clinical study of copy number variation (CNV). Twenty-three samples were classified as eligible for CNV detection, 29 samples as ineligible and 25 were classified as being of inte...

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