Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives
Abstract
:1. Introduction
2. Experimental Section
3. MicroRNAs in Cardiovascular Development
Differentially expressed microRNAs | Cardio-vascular role | Validated targets (cardiovascular role) | Cardiac formation | iPS cardio-myogenesis | Cardiac aging | References |
---|---|---|---|---|---|---|
let-7a | nras, kras, hmga2 | up | up | down | [24] | |
let-7b | up | up | na | |||
let-7c | up | up | na | |||
let-7d | up | up | na | |||
let-7i | up | up | na | |||
miR-15b | miR-15 | dmtf1, c22orf5, bcl-2, Chek1 | up | down | na | [18,24] |
miR-17 | miR-17 | rbl2-p130, ncoa3, e2f1, adkcnna-p21, fog2 | up | na | na | [24,25,26] |
miR-23b | miR-23 | pou4f2, hes1, has2 | up | up | na | [24,27] |
miR-24 | miR-24 | notch1,mapk14, kiaa0152, dhfr, cdkn2a-p16, alk4, gata2, pak4, bcl2 | up | up | na | [24,28,29] |
miR-25 | miR-25 | na | up | down | na | |
miR-26a | up | up | na | |||
miR-30a | miR-30 | ctgf, znf294, wnt5a, uap1, tnfrsf10b, tnfaip2, tmem87a, tmem59, tmem41b, tmed7, tmed3, tmed2, tmed10, tmco1, tloc1, ticam2, them4, sypl1, stx7, strn, slc9a3r2, slc9a3r2, slc7a11, slc7a1, slc4a7, slo4a10, slc38a2, slc38a1, slc12a4, sec23a, rpcd1, rbms1, rad23b, rab27b, ptrh1, ptprk, ptgfrn, prpf40a, ppp3r1, ppp3ca, ppp2r4, pgm1, ptprk, ptgfrn, prpf40a, ppp3r1, ppp3ca, ppp2r4, pgm1, pex11b, pafah1b2, pfha2, nufip2, nucb1, nt5e, nt5c3, npr3, np, ncl, napg, myo10, mpdu1, mllt11, mllt1, met, mbnl1, mat2a, lrrc8c, lmnb2, krthb5, kdelc2, jun, itga2, ifrd1, idh1, hnrpm, gpd2, gnai2, gilnt7, galnt1, fxr2, frg1, f2, elmod2, dock7, cpne8, chd1 | up | na | na | [30,31,32] |
miR-30d | up | up | na | |||
miR-93 | miR-93 | na | up | down | na | |
miR-99a | up | up | up | |||
miR-99b | up | up | na | |||
miR-103 | up | down | na | |||
miR-106a | up | down | down | |||
miR-122a | miR-122 | trpr6, ndrg3, cd320, bckdk, aldoa, cck-8, caspase-3 | up | na | na | [24,33] |
miR-125a | miR-125 | Lin28, erbb2, erbb3, zfp385, tor2a, rhebl1, ppt2, mkk7, lin28, jub, entpd4, dus11, ddx19b, arid3b, arid3a, apln, abtb1 | up | na | na | [24] |
miR-125b | up | up | na | |||
miR-126 | miR-126 | vam1 | up | down | na | [24] |
miR-130a | up | down | na | |||
miR-130b | up | down | na | |||
miR-133a | miR-133 | srf, ptp2, kcne1, hcn2, hcn4, erg, casp9, nfatc4 | up | up | na | [24,34,35,36] |
miR-133b | up | up | na | |||
miR-140 | up | na | na | |||
miR-143 | miR-143 | mapk7, mapk12, aduccine3 | up | up | na | [24,37] |
miR-145 | miR-145 | irs-1, flj21308, dab2 | up | up | na | [24,38] |
miR-181a | up | up | na | |||
miR-181b | up | up | na | |||
miR-183 | up | up | na | |||
miR-190 | up | up | na | |||
miR-191 | up | up | na | |||
miR-198 * | up | up | na | |||
miR-202 | up | up | na | |||
miR-210 | miR-210 | efna3 | up | up | na | [24] |
miR-298 | up | na | equal | |||
miR-320 | up | na | na | |||
miR-322 ** | miR-322 | na | up | na | up | |
miR-324 | up | down | na | |||
miR-351 ** | up | na | equal | |||
miR-373 * | up | down | na | |||
miR-422b | up | na | na | |||
miR-453 | up | up | na | |||
miR-455 | up | na | na | |||
miR-494 | miR-494 | na | up | up | down | |
miR-494 | up | na | na | |||
miR-503 | up | na | down | |||
miR-513 ** | up | na | na | |||
miR-517 ** | up | na | na | |||
miR-518c | up | na | na | |||
miR-546 * | up | na | equal |
4. A Meta-Analysis of MicroRNA Microarrays in Cardiogenesis and Cardiac Aging
5. The Cardiovascular Role of Differentially Expressed MicroRNAs during Ventricular Development
6. Conclusions & Perspectives
Acknowledgments
Conflict of interest
References
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Bonet, F.; Hernandez-Torres, F.; Esteban, F.J.; Aranega, A.; Franco, D. Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives. Microarrays 2013, 2, 81-96. https://doi.org/10.3390/microarrays2020081
Bonet F, Hernandez-Torres F, Esteban FJ, Aranega A, Franco D. Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives. Microarrays. 2013; 2(2):81-96. https://doi.org/10.3390/microarrays2020081
Chicago/Turabian StyleBonet, Fernando, Francisco Hernandez-Torres, Franciso J. Esteban, Amelia Aranega, and Diego Franco. 2013. "Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives" Microarrays 2, no. 2: 81-96. https://doi.org/10.3390/microarrays2020081