Stimulation of the Angular Gyrus Improves the Level of Consciousness
Liudmila Legostaeva *, Alexandra Poydasheva
, Elizaveta Iazeva, Dmitry Sinitsyn, Dmitry Sergeev, Ilya Bakulin, Dmitry Lagoda, Elena Kremneva, Sofya Morozova, Yulia Ryabinkina, Natalia Suponeva and Michael Piradov
, Elizaveta Iazeva, Dmitry Sinitsyn, Dmitry Sergeev, Ilya Bakulin, Dmitry Lagoda, Elena Kremneva, Sofya Morozova, Yulia Ryabinkina, Natalia Suponeva and Michael Piradov
Research Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, Russia
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(5), 103; https://doi.org/10.3390/brainsci9050103
Received: 19 March 2019 / Revised: 2 May 2019 / Accepted: 5 May 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Advances in Disorders of Consciousness)
Abstract
Background: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively correlated with the level of consciousness. Our study aimed to explore the effect of rTMS of the angular gyrus as a new approach for disorders of consciousness (DOC) treatment; Methods: A 10-session 2-week high-frequency rTMS protocol was delivered over the left angular gyrus in 38 DOC patients with repeated neurobehavioral assessments obtained at baseline and in 2 days after the stimulation course was complete; Results: 20 Hz-rTMS over left angular gyrus improved the coma recovery scale revised (CRS-R) total score in minimally conscious state (MCS) patients. We observed no effects in vegetative state (VS) patients; and Conclusions: The left angular gyrus is likely to be effective target for rTMS in patients with present signs of consciousness. View Full-TextKeywords:
disorders of consciousness; angular gyrus; repetitive transcranial magnetic stimulation; neuromodulation; vegetative state; non-invasive brain stimulation
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Legostaeva, L.; Poydasheva, A.; Iazeva, E.; Sinitsyn, D.; Sergeev, D.; Bakulin, I.; Lagoda, D.; Kremneva, E.; Morozova, S.; Ryabinkina, Y.; Suponeva, N.; Piradov, M. Stimulation of the Angular Gyrus Improves the Level of Consciousness. Brain Sci. 2019, 9, 103.
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