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Intracerebral Hemorrhage: Blood Components and Neurotoxicity

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Brain Sci. 2019, 9(11), 316; https://doi.org/10.3390/brainsci9110316
Received: 26 September 2019 / Revised: 30 October 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH. View Full-Text
Keywords: ICH; hemin; thrombin; hemoglobin; iron ICH; hemin; thrombin; hemoglobin; iron
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Madangarli, N.; Bonsack, F.; Dasari, R.; Sukumari–Ramesh, S. Intracerebral Hemorrhage: Blood Components and Neurotoxicity. Brain Sci. 2019, 9, 316.

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