Next Article in Journal
Sex Differences and the Influence of Sex Hormones on Cognition through Adulthood and the Aging Process
Previous Article in Journal
Social Cognition and Oxytocin in Huntington’s Disease: New Insights
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Brain Sci. 2018, 8(9), 162; https://doi.org/10.3390/brainsci8090162

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease

1
Department of Pharmacy, BRAC University, Dhaka 1212, Bangladesh
2
Harvard Medical School, Harvard University, Boston, MA 02114, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 22 July 2018 / Revised: 24 August 2018 / Accepted: 24 August 2018 / Published: 26 August 2018
Full-Text   |   PDF [5127 KB, uploaded 26 August 2018]   |  

Abstract

One of the most commonly known chronic neurodegenerative disorders, Alzheimer’s disease (AD), manifests the common type of dementia in 60–80% of cases. From a clinical standpoint, a patent cognitive decline and a severe change in personality, as caused by a loss of neurons, is usually evident in AD with about 50 million people affected in 2016. The disease progression in patients is distinguished by a gradual plummet in cognitive functions, eliciting symptoms such as memory loss, and eventually requiring full-time medical care. From a histopathological standpoint, the defining characteristics are intracellular aggregations of hyper-phosphorylated tau protein, known as neurofibrillary tangles (NFT), and depositions of amyloid β-peptides (Aβ) in the brain. The abnormal phosphorylation of tau protein is attributed to a wide gamut of neurological disorders known as tauopathies. In addition to the hyperphosphorylated tau lesions, neuroinflammatory processes could occur in a sustained manner through astro-glial activation, resulting in the disease progression. Recent findings have suggested a strong interplay between the mechanism of Tau phosphorylation, disruption of microtubules, and synaptic loss and pathology of AD. The mechanisms underlying these interactions along with their respective consequences in Tau pathology are still ill-defined. Thus, in this review: (1) we highlight the interplays existing between Tau pathology and AD; and (2) take a closer look into its role while identifying some promising therapeutic advances including state of the art imaging techniques. View Full-Text
Keywords: protein tau; Alzheimer’s disease; neurodegenerative disease; synaptic dysfunction; Aβ-peptides; tau-imaging protein tau; Alzheimer’s disease; neurodegenerative disease; synaptic dysfunction; Aβ-peptides; tau-imaging
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Islam Khan, R.; Nirzhor, S.S.R.; Rashid, B. A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease. Brain Sci. 2018, 8, 162.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top