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Down Syndrome, Obesity, Alzheimer’s Disease, and Cancer: A Brief Review and Hypothesis

1
Cancer Treatment Centers of America, Southeastern Regional Medical Center, Newnan, GA 30265, USA
2
Morehouse School of Medicine, Atlanta, GA 30310, USA
Brain Sci. 2018, 8(4), 53; https://doi.org/10.3390/brainsci8040053
Received: 24 February 2018 / Revised: 15 March 2018 / Accepted: 22 March 2018 / Published: 24 March 2018
Down syndrome (trisomy 21), a complex mix of physical, mental, and biochemical issues, includes an increased risk of Alzheimer’s disease and childhood leukemia, a decreased risk of other tumors, and a high frequency of overweight/obesity. Certain features related to the third copy of chromosome 21 (which carries the APP gene and several anti-angiogenesis genes) create an environment favorable for Alzheimer’s disease and unfavorable for cancer. This environment may be enhanced by two bioactive compounds from fat cells, leptin, and adiponectin. This paper outlines these fat-related disease mechanisms and suggests new avenues of research to reduce disease risk in Down syndrome. View Full-Text
Keywords: down syndrome; cancer; Alzheimer’s disease; obesity; leptin; adiponectin down syndrome; cancer; Alzheimer’s disease; obesity; leptin; adiponectin
MDPI and ACS Style

Nixon, D.W. Down Syndrome, Obesity, Alzheimer’s Disease, and Cancer: A Brief Review and Hypothesis. Brain Sci. 2018, 8, 53.

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