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Acute Regression in Young People with Down Syndrome

Jérôme Lejeune Institute, Paris 75015, France
Author to whom correspondence should be addressed.
Academic Editor: Alberto Costa
Brain Sci. 2017, 7(6), 57;
Received: 13 April 2017 / Revised: 19 May 2017 / Accepted: 24 May 2017 / Published: 27 May 2017
(This article belongs to the Special Issue Cognitive Dysfunction in Down Syndrome)
Abstract: Adolescents and young adults with Down syndrome (DS) can present a rapid regression with loss of independence and daily skills. Causes of regression are unknown and treatment is most of the time symptomatic. We did a retrospective cohort study of regression cases: patients were born between 1959 and 2000, and were followed from 1984 to now. We found 30 DS patients aged 11 to 30 years old with history of regression. Regression occurred regardless of the cognitive level (severe, moderate, or mild intellectual disability (ID)). Patients presented psychiatric symptoms (catatonia, depression, delusions, stereotypies, etc.), partial or total loss of independence in activities of daily living (dressing, toilet, meals, and continence), language impairment (silence, whispered voice, etc.), and loss of academic skills. All patients experienced severe emotional stress prior to regression, which may be considered the trigger. Partial or total recovery was observed for about 50% of them. In our cohort, girls were more frequently affected than boys (64%). Neurobiological hypotheses are discussed as well as preventative and therapeutic approaches. View Full-Text
Keywords: down syndrome; adolescence; regression; neurobiology down syndrome; adolescence; regression; neurobiology
MDPI and ACS Style

Mircher, C.; Cieuta-Walti, C.; Marey, I.; Rebillat, A.-S.; Cretu, L.; Milenko, E.; Conte, M.; Sturtz, F.; Rethore, M.-O.; Ravel, A. Acute Regression in Young People with Down Syndrome. Brain Sci. 2017, 7, 57.

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