Self-Injury in Autism Spectrum Disorder and Intellectual Disability: Exploring the Role of Reactivity to Pain and Sensory Input
Reviewer 1 Report
very interesting review article
Thank you very much for reviewing our manuscript.
Reviewer 2 Report
This is an interesting MS on an aspect of ASD that has now a resurgence of interest. The paper is informative and well written. It is also useful for clinicians.
I have some questions of general interest.
The role of neurochemical disorders in SIBs is poorly discussed. The reader could expect more on this topic.
Are there animal models?
The Lesch-Nyhan syndrome is probably the paragon of SIBs. It should be useful to draw the consequences of the molecular analyzes performed with the syndrome. Are the results useful for understanding the mechanisms of SIBs in ASD? Does HGPRT proteins interacts with the product of genes implicated in ASD. This could be analyzed with tools for the analysis of interactions between proteins (David, Strings among others).
Line 114: Multiple forms of SIBS… Is there some attempt to make a classification?
Are GWAS in progress on SIBS?
Thank you very much for your comments and suggestions on our submission. We will respond to each of them in detail.
Role of neurochemical disorders in SIB - include more information on this topic. We have included a reference to different neurochemical correlates of SIB in the MS (lines 272-274).
Animal models of SIB - we have included information about mouse and non-human primate models as well as inducing SIB in rodents via injections of pemoline (lines 108-117).
Lesch Nyhan, molecular analyses and implications for understanding the mechanisms of SIB in ASD; HGPRT protein interaction with the product of genes implicated in ASD. This particular topic is outside our expertise and as such we do not feel qualified to provide a response.
Multiple forms of SIB (formerly line 114; now line 128) - we have changed the wording to topographies rather than types of SIB to be clearer and avoid possible confusion.
Genome wide association studies on SIBs - this topic is outside our expertise and we don't feel qualified to provide a response.
To the Editor: please note - we have included additional references to correspond with our revisions all will format these references pending approval of our revisions.
Author Response File: Author Response.docx