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Brain Sci. 2016, 6(4), 49;

Corticospinal Excitability in Children with Congenital Hemiparesis

Department of Physical Medicine and Rehabilitation, College of Medicine, University of Minnesota, MMC 297, 420 Delaware St SE, Minneapolis, MN 55455, USA
Department of Neurology, University of California, Irvine, Hewitt Hall, Room 1331, Irvine, CA 92697, USA
Author to whom correspondence should be addressed.
Academic Editor: Sheila Schindler-Ivens
Received: 29 July 2016 / Revised: 20 September 2016 / Accepted: 14 October 2016 / Published: 20 October 2016
(This article belongs to the Special Issue Functional Recovery after Stroke)
Full-Text   |   PDF [787 KB, uploaded 20 October 2016]   |  


Transcranial magnetic stimulation (TMS) can be used as an assessment or intervention to evaluate or influence brain activity in children with hemiparetic cerebral palsy (CP) commonly caused by perinatal stroke. This communication report analyzed data from two clinical trials using TMS to assess corticospinal excitability in children and young adults with hemiparetic CP. The results of this communication revealed a higher probability of finding a motor evoked potential (MEP) on the non-lesioned hemisphere compared to the lesioned hemisphere (p = 0.005). The resting motor threshold (RMT) was lower on the non-lesioned hemisphere than the lesioned hemisphere (p = 0.013). There was a significantly negative correlation between age and RMT (rs = −0.65, p = 0.003). This communication provides information regarding MEP responses, motor thresholds (MTs) and the association with age during TMS assessment in children with hemiparetic CP. Such findings contribute to the development of future pediatric studies in neuroplasticity and neuromodulation to influence motor function and recovery after perinatal stroke. View Full-Text
Keywords: transcranial magnetic stimulation; motor evoked potential; motor threshold; perinatal stroke; cerebral palsy transcranial magnetic stimulation; motor evoked potential; motor threshold; perinatal stroke; cerebral palsy

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Chen, C.-Y.; Rich, T.L.; Cassidy, J.M.; Gillick, B.T. Corticospinal Excitability in Children with Congenital Hemiparesis. Brain Sci. 2016, 6, 49.

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