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Volume 12
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10.3390/brainsci12081048
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Article

Prediction of Cognitive Degeneration in Parkinson’s Disease Patients Using a Machine Learning Method

by
Pei-Hao Chen
1,2,
Ting-Yi Hou
3,
Fang-Yu Cheng
2 and
Jin-Siang Shaw
3,*
1
Department of Neurology, MacKay Memorial Hospital, Taipei 104217, Taiwan
2
Institute of Long-Term Care, Mackay Medical College, New Taipei City 252, Taiwan
3
Institute of Mechatronic Engineering, National Taipei University of Technology, Taipei 106344, Taiwan
*
Author to whom correspondence should be addressed.
Brain Sci. 2022, 12(8), 1048; https://doi.org/10.3390/brainsci12081048
Submission received: 9 July 2022 / Revised: 31 July 2022 / Accepted: 6 August 2022 / Published: 7 August 2022
(This article belongs to the Special Issue From Bench to Bedside: Motor-Cognitive Interactions)
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Abstract

This study developed a predictive model for cognitive degeneration in patients with Parkinson’s disease (PD) using a machine learning method. The clinical data, plasma biomarkers, and neuropsychological test results of patients with PD were collected and utilized as model predictors. Machine learning methods comprising support vector machines (SVMs) and principal component analysis (PCA) were applied to obtain a cognitive classification model. Using 32 comprehensive predictive parameters, the PCA-SVM classifier reached 92.3% accuracy and 0.929 area under the receiver operating characteristic curve (AUC). Furthermore, the accuracy could be increased to 100% and the AUC to 1.0 in a PCA-SVM model using only 13 carefully chosen features.
Keywords: Parkinson’s disease; machine learning; neuropsychological test; biomarker Parkinson’s disease; machine learning; neuropsychological test; biomarker

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MDPI and ACS Style

Chen, P.-H.; Hou, T.-Y.; Cheng, F.-Y.; Shaw, J.-S. Prediction of Cognitive Degeneration in Parkinson’s Disease Patients Using a Machine Learning Method. Brain Sci. 2022, 12, 1048. https://doi.org/10.3390/brainsci12081048

AMA Style

Chen P-H, Hou T-Y, Cheng F-Y, Shaw J-S. Prediction of Cognitive Degeneration in Parkinson’s Disease Patients Using a Machine Learning Method. Brain Sciences. 2022; 12(8):1048. https://doi.org/10.3390/brainsci12081048

Chicago/Turabian Style

Chen, Pei-Hao, Ting-Yi Hou, Fang-Yu Cheng, and Jin-Siang Shaw. 2022. "Prediction of Cognitive Degeneration in Parkinson’s Disease Patients Using a Machine Learning Method" Brain Sciences 12, no. 8: 1048. https://doi.org/10.3390/brainsci12081048

APA Style

Chen, P.-H., Hou, T.-Y., Cheng, F.-Y., & Shaw, J.-S. (2022). Prediction of Cognitive Degeneration in Parkinson’s Disease Patients Using a Machine Learning Method. Brain Sciences, 12(8), 1048. https://doi.org/10.3390/brainsci12081048

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