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Volume 12
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10.3390/brainsci12020123
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Article

The Clinical Features of In-Hospital Recurrence in Acute Ischaemic Stroke Patients over Time: A Real-World Observation at a Single Center

by
Gaoqi Zhang
1,
Qiong Yang
1,
Huagang Zhang
1,
Xiao Huang
1,
Yu Fu
1,* and
Dongsheng Fan
1,2,*
1
Department of Neurology, Peking University Third Hospital, Beijing 100191, China
2
Key Laboratory for Neuroscience, National Health Commission/Ministry of Education, Peking University, Beijing 100191, China
*
Authors to whom correspondence should be addressed.
Brain Sci. 2022, 12(2), 123; https://doi.org/10.3390/brainsci12020123
Submission received: 3 December 2021 / Revised: 14 January 2022 / Accepted: 15 January 2022 / Published: 18 January 2022
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Abstract

Acute ischaemic stroke (AIS) has a high risk of recurrence, particularly in the early stage. Our study aimed to assess the clinical characteristics and risk factors of in-hospital ischaemic recurrence in AIS patients in different periods. This study was a retrospective, single-center analysis. The patients were divided into two stages based on their admission time. The primary endpoint was recurrent stroke during hospitalization. In total, 978 patients in Stage 1 and 1047 patients in Stage 2 were included in this study. The in-hospital recurrence rate in Stage 1 was 5.9%, while that in Stage 2 was 4.0% (p = 0.046). A recurrence rate reduction mainly occurred in the minor stroke and large-artery atherosclerosis (LAA) stroke patients. Infection was an independent risk factor despite amelioration by antiplatelet therapy (p < 0.001). Diabetes patients also had a higher risk of in-hospital ischaemic recurrence among the minor stroke and large-artery atherosclerosis patients. A positive attitude towards antiplatelet therapy failed to completely halt recurrence of the disease. In conclusion, the rate of in-hospital ischaemic recurrence in AIS patients showed a decreasing trend over time, especially in the minor stroke and large-artery atherosclerosis stroke patients. Infection and diabetes were associated with a higher risk of stroke recurrence.
Keywords: ischaemic stroke; antiplatelet therapy; risk factors ischaemic stroke; antiplatelet therapy; risk factors

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MDPI and ACS Style

Zhang, G.; Yang, Q.; Zhang, H.; Huang, X.; Fu, Y.; Fan, D. The Clinical Features of In-Hospital Recurrence in Acute Ischaemic Stroke Patients over Time: A Real-World Observation at a Single Center. Brain Sci. 2022, 12, 123. https://doi.org/10.3390/brainsci12020123

AMA Style

Zhang G, Yang Q, Zhang H, Huang X, Fu Y, Fan D. The Clinical Features of In-Hospital Recurrence in Acute Ischaemic Stroke Patients over Time: A Real-World Observation at a Single Center. Brain Sciences. 2022; 12(2):123. https://doi.org/10.3390/brainsci12020123

Chicago/Turabian Style

Zhang, Gaoqi, Qiong Yang, Huagang Zhang, Xiao Huang, Yu Fu, and Dongsheng Fan. 2022. "The Clinical Features of In-Hospital Recurrence in Acute Ischaemic Stroke Patients over Time: A Real-World Observation at a Single Center" Brain Sciences 12, no. 2: 123. https://doi.org/10.3390/brainsci12020123

APA Style

Zhang, G., Yang, Q., Zhang, H., Huang, X., Fu, Y., & Fan, D. (2022). The Clinical Features of In-Hospital Recurrence in Acute Ischaemic Stroke Patients over Time: A Real-World Observation at a Single Center. Brain Sciences, 12(2), 123. https://doi.org/10.3390/brainsci12020123

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