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Abnormal Functional Network Topology and Its Dynamics during Sustained Attention Processing Significantly Implicate Post-TBI Attention Deficits in Children
Article

Regional Topological Aberrances of White Matter- and Gray Matter-Based Functional Networks for Attention Processing May Foster Traumatic Brain Injury-Related Attention Deficits in Adults

by 1, 2, 2, 3, 4,5 and 1,2,*
1
Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
2
Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
3
School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510630, China
4
Department of Psychology, Brooklyn College, The City University of New York, New York, NY 11210, USA
5
The Graduate Center, The City University of New York, New York, NY 10016, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ardalan Aarabi
Brain Sci. 2022, 12(1), 16; https://doi.org/10.3390/brainsci12010016
Received: 30 November 2021 / Revised: 21 December 2021 / Accepted: 22 December 2021 / Published: 24 December 2021
(This article belongs to the Special Issue Brain Dynamics and Connectivity from Birth through Adulthood)
Traumatic brain injury (TBI) is highly prevalent in adults. TBI-related functional brain alterations have been linked with common post-TBI neurobehavioral sequelae, with unknown neural substrates. This study examined the systems-level functional brain alterations in white matter (WM) and gray matter (GM) for visual sustained-attention processing, and their interactions and contributions to post-TBI attention deficits. Task-based functional MRI data were collected from 42 adults with TBI and 43 group-matched normal controls (NCs), and analyzed using the graph theoretic technique. Global and nodal topological properties were calculated and compared between the two groups. Correlation analyses were conducted between the neuroimaging measures that showed significant between-group differences and the behavioral symptom measures in attention domain in the groups of TBI and NCs, respectively. Significantly altered nodal efficiencies and/or degrees in several WM and GM nodes were reported in the TBI group, including the posterior corona radiata (PCR), posterior thalamic radiation (PTR), postcentral gyrus (PoG), and superior temporal sulcus (STS). Subjects with TBI also demonstrated abnormal systems-level functional synchronization between the PTR and STS in the right hemisphere, hypo-interaction between the PCR and PoG in the left hemisphere, as well as the involvement of systems-level functional aberrances in the PCR in TBI-related behavioral impairments in the attention domain. The findings of the current study suggest that TBI-related systems-level functional alterations associated with these two major-association WM tracts, and their anatomically connected GM regions may play critical role in TBI-related behavioral deficits in attention domains. View Full-Text
Keywords: traumatic brain injury (TBI); post-TBI attention deficits; visual sustained-attention task (VSAT); graph theoretic technique (GTT); white matter tracts traumatic brain injury (TBI); post-TBI attention deficits; visual sustained-attention task (VSAT); graph theoretic technique (GTT); white matter tracts
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MDPI and ACS Style

Wu, Z.; Cao, M.; Di, X.; Wu, K.; Gao, Y.; Li, X. Regional Topological Aberrances of White Matter- and Gray Matter-Based Functional Networks for Attention Processing May Foster Traumatic Brain Injury-Related Attention Deficits in Adults. Brain Sci. 2022, 12, 16. https://doi.org/10.3390/brainsci12010016

AMA Style

Wu Z, Cao M, Di X, Wu K, Gao Y, Li X. Regional Topological Aberrances of White Matter- and Gray Matter-Based Functional Networks for Attention Processing May Foster Traumatic Brain Injury-Related Attention Deficits in Adults. Brain Sciences. 2022; 12(1):16. https://doi.org/10.3390/brainsci12010016

Chicago/Turabian Style

Wu, Ziyan, Meng Cao, Xin Di, Kai Wu, Yu Gao, and Xiaobo Li. 2022. "Regional Topological Aberrances of White Matter- and Gray Matter-Based Functional Networks for Attention Processing May Foster Traumatic Brain Injury-Related Attention Deficits in Adults" Brain Sciences 12, no. 1: 16. https://doi.org/10.3390/brainsci12010016

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