Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons
Abstract
:1. Introduction
2. Pros
2.1. Anti-Oxygen
2.2. Anti-ROS
2.3. Anti-Obesity
2.4. Increased CO2 Production
2.5. Increased Mitophagic Activity
2.6. Increased Mitochondrial Biogenesis
2.7. Enhanced AMPK Signaling
2.8. Anti-Inflammatory
3. Cons
3.1. Possibility of Local Hypoxia/Ischemia
3.2. The Drop of ATP Synthesis
3.3. Acidic Shift
3.4. The Drop of the Membrane Potential-Dependent Reactions
3.5. Diminished Mitophagic Activity?
3.6. Hyperactivation of Oxidative Metabolism, Loss of Cellular Reserves
3.7. Reduction of Redox Signaling
3.8. Thermogenesis
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Zorov, D.B.; Andrianova, N.V.; Babenko, V.A.; Pevzner, I.B.; Popkov, V.A.; Zorov, S.D.; Zorova, L.D.; Plotnikov, E.Y.; Sukhikh, G.T.; Silachev, D.N. Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons. Brain Sci. 2021, 11, 1050. https://doi.org/10.3390/brainsci11081050
Zorov DB, Andrianova NV, Babenko VA, Pevzner IB, Popkov VA, Zorov SD, Zorova LD, Plotnikov EY, Sukhikh GT, Silachev DN. Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons. Brain Sciences. 2021; 11(8):1050. https://doi.org/10.3390/brainsci11081050
Chicago/Turabian StyleZorov, Dmitry B., Nadezda V. Andrianova, Valentina A. Babenko, Irina B. Pevzner, Vasily A. Popkov, Savva D. Zorov, Ljubava D. Zorova, Egor Yu. Plotnikov, Gennady T. Sukhikh, and Denis N. Silachev. 2021. "Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons" Brain Sciences 11, no. 8: 1050. https://doi.org/10.3390/brainsci11081050