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Article

Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome

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Department of Basic Medical Sciences, Faculty of Medicine, Hashemite University, Zarqa 13133, Jordan
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Department of Medical Physiology, Faculty of Medicine, Cairo University, Cairo 11451, Egypt
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Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo 11451, Egypt
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Division of Neurosurgery, Department of Surgery, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia
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Department of Pharmacology, Faculty of Medicine, Benha University, Benha 13511, Egypt
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Department of Biochemistry, Faculty of Medicine, Benha University, Benha 13511, Egypt
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Authors to whom correspondence should be addressed.
Academic Editor: Rita Barone
Brain Sci. 2021, 11(5), 644; https://doi.org/10.3390/brainsci11050644
Received: 29 March 2021 / Revised: 4 May 2021 / Accepted: 11 May 2021 / Published: 15 May 2021
Metabolic Syndrome (MetS) is considered a common disorder, especially with a sedentary lifestyle and unhealthy food consumption. Cognitive impairment is one of the MetS consequences that worsens the quality of life of the patients. The study aimed to assess the therapeutic effect of the neurosteroid Allopregnalonone on spatial memory and, therefore, the expression of two synaptic plasticity markers in the hippocampus. Thirty-two male rats were divided into four groups: control groups, MetS, and MetS + Allopregnalone. Spatial memory has been evaluated by the Y-maze task and blood pressure measured by the rat tail method. Biochemical evaluation of serum glucose, insulin, lipid profile, and hippocampal expression of Synaptophysin and Associated Protein 43 (GAP-43) were performed for assessing Allopregnanolone on serum and hippocampal markers. Allopregnanolone therapy improved working spatial memory, hypertension, and biochemical markers measured in the serum and hippocampus. View Full-Text
Keywords: metabolic syndrome; spatial memory; synaptic plasticity; synaptophysin; GAP-43; allopregnanolone metabolic syndrome; spatial memory; synaptic plasticity; synaptophysin; GAP-43; allopregnanolone
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MDPI and ACS Style

Amin, S.N.; Abdalgeleel, S.A.; Algahtany, M.A.; Shaltout, S.A.; El Gazzar, W.B.; Elberry, D.A. Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome. Brain Sci. 2021, 11, 644. https://doi.org/10.3390/brainsci11050644

AMA Style

Amin SN, Abdalgeleel SA, Algahtany MA, Shaltout SA, El Gazzar WB, Elberry DA. Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome. Brain Sciences. 2021; 11(5):644. https://doi.org/10.3390/brainsci11050644

Chicago/Turabian Style

Amin, Shaimaa N., Shaimaa A. Abdalgeleel, Mubarak A. Algahtany, Sherif A. Shaltout, Walaa B. El Gazzar, and Dalia A. Elberry 2021. "Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome" Brain Sciences 11, no. 5: 644. https://doi.org/10.3390/brainsci11050644

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