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Article

Disrupted Pallido-Thalamo-Cortical Functional Connectivity in Chronic Disorders of Consciousness

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Institut Pascal, Université Clermont Auvergne, Centre National de la Recherche Scientifique, Institut National Polytechnique-Clermont, Centre Hospitalier Universitaire de Clermont-Ferrand, F-63000 Clermont-Ferrand, France
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Service de Radiologie, Unité de Neuroradiologie, Centre Hospitalier Universitaire de Clermont-Ferrand, F-63000 Clermont-Ferrand, France
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Author to whom correspondence should be addressed.
Academic Editor: Olivia Gosseries
Brain Sci. 2021, 11(3), 356; https://doi.org/10.3390/brainsci11030356
Received: 20 January 2021 / Revised: 8 March 2021 / Accepted: 9 March 2021 / Published: 11 March 2021
(This article belongs to the Special Issue Recent Advances in the Study of Altered State of Consciousness)
Chronic disorders of consciousness (DOC) encompass unresponsive wakefulness syndrome and minimally conscious state. Their anatomo-functional correlates are not clearly defined yet, although impairments of functional cortical networks have been reported, as well as the implication of the thalamus and deep brain structures. However, the pallidal functional connectivity with the thalamus and the cortical networks has not been studied so far. Using resting-state functional MRI, we conducted a functional connectivity study between the pallidum, the thalamus and the cortical networks in 13 patients with chronic DOC and 19 healthy subjects. We observed in chronic DOC patients that the thalami were no longer connected to the cortical networks, nor to the pallidums. Concerning the functional connectivity of pallidums, we reported an abolition of the negative correlation with the default mode network, and of the positive correlation with the salience network. The disrupted functional connectivity observed in chronic DOC patients between subcortical structures and cortical networks could be related to the mesocircuit model. A better understanding of the DOC underlying physiopathology could provide food for thought for future therapeutic proposals. View Full-Text
Keywords: cerebral networks; disorders of consciousness; functional resting-state connectivity; mesocircuit model; pallidum; thalamus cerebral networks; disorders of consciousness; functional resting-state connectivity; mesocircuit model; pallidum; thalamus
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MDPI and ACS Style

Sontheimer, A.; Pontier, B.; Claise, B.; Chassain, C.; Coste, J.; Lemaire, J.-J. Disrupted Pallido-Thalamo-Cortical Functional Connectivity in Chronic Disorders of Consciousness. Brain Sci. 2021, 11, 356. https://doi.org/10.3390/brainsci11030356

AMA Style

Sontheimer A, Pontier B, Claise B, Chassain C, Coste J, Lemaire J-J. Disrupted Pallido-Thalamo-Cortical Functional Connectivity in Chronic Disorders of Consciousness. Brain Sciences. 2021; 11(3):356. https://doi.org/10.3390/brainsci11030356

Chicago/Turabian Style

Sontheimer, Anna, Bénédicte Pontier, Béatrice Claise, Carine Chassain, Jérôme Coste, and Jean-Jacques Lemaire. 2021. "Disrupted Pallido-Thalamo-Cortical Functional Connectivity in Chronic Disorders of Consciousness" Brain Sciences 11, no. 3: 356. https://doi.org/10.3390/brainsci11030356

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