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Article

Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study

1
Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia, 27100 Pavia, Italy
2
Department of Neurology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy
3
Department of Surgery and Medical-Surgery Specialties, University of Catania, 95123 Catania, Italy
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Division of Pulmonary and Sleep Medicine, Seattle Children’s Hospital, 4800 Sand Point Way, Seattle, WA 98105, USA
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IRCCS, Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy
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Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
7
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Marco Fabbri
Brain Sci. 2021, 11(12), 1574; https://doi.org/10.3390/brainsci11121574
Received: 19 October 2021 / Revised: 24 November 2021 / Accepted: 25 November 2021 / Published: 28 November 2021
(This article belongs to the Section Behavioral Neuroscience)
The objectives of this study were: (1) to identify subjects with hyperprolactinemia in a clinical sample of patients; (2) to compare the neurologic, psychiatric, and sleep conditions found in patients subgrouped by excessive daytime sleepiness (EDS) and hyperprolactinemia; and (3) to identify patients with hyperprolactinemia and EDS not supported by the presence of any other neurologic, psychiatric, or sleep disorder, or substance/medication use. A retrospective chart review of inpatients was carried out in order to identify all patients in whom the prolactin (PRL) serum levels were determined. A total of 130 subjects were retrieved: 55 had increased levels of PRL, while the remaining 75 participants had normal PRL levels. EDS was reported by 32 (58.2%) participants with increased PRL and 34 (45.3%) with normal PRL. Obstructive sleep apnea or other sleep or neurologic/psychiatric conditions could explain EDS in all participants with normal PRL. Among subjects with increased PRL, eight had no other neurologic/psychiatric or sleep disorder (or drug) potentially causing EDS; these participants, at polysomnography, had time in bed, sleep period time, and total sleep time longer than those with EDS associated to another condition. These findings can be considered as a preliminary indication of a role of hyperprolactinemia in EDS and represent a basis for future controlled studies able to test this hypothesis in a reliable, objective, and methodologically more appropriate way. View Full-Text
Keywords: prolactin; hypersomnia; excessive daytime sleepiness; comorbidity; sleep disorders; observational study prolactin; hypersomnia; excessive daytime sleepiness; comorbidity; sleep disorders; observational study
MDPI and ACS Style

Mogavero, M.P.; Cosentino, F.I.I.; Lanuzza, B.; Tripodi, M.; Lanza, G.; Aricò, D.; DelRosso, L.M.; Pizza, F.; Plazzi, G.; Ferri, R. Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study. Brain Sci. 2021, 11, 1574. https://doi.org/10.3390/brainsci11121574

AMA Style

Mogavero MP, Cosentino FII, Lanuzza B, Tripodi M, Lanza G, Aricò D, DelRosso LM, Pizza F, Plazzi G, Ferri R. Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study. Brain Sciences. 2021; 11(12):1574. https://doi.org/10.3390/brainsci11121574

Chicago/Turabian Style

Mogavero, Maria P., Filomena I.I. Cosentino, Bartolo Lanuzza, Mariangela Tripodi, Giuseppe Lanza, Debora Aricò, Lourdes M. DelRosso, Fabio Pizza, Giuseppe Plazzi, and Raffaele Ferri. 2021. "Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study" Brain Sciences 11, no. 12: 1574. https://doi.org/10.3390/brainsci11121574

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