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Post-COVID-19 Fatigue: Potential Contributing Factors

Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(12), 1012;
Received: 21 November 2020 / Revised: 16 December 2020 / Accepted: 17 December 2020 / Published: 19 December 2020
Much of the spotlight for coronavirus disease 2019 (COVID-19) is on the acute symptoms and recovery. However, many recovered patients face persistent physical, cognitive, and psychological symptoms well past the acute phase. Of these symptoms, fatigue is one of the most persistent and debilitating. In this “perspective article,” we define fatigue as the decrease in physical and/or mental performance that results from changes in central, psychological, and/or peripheral factors due to the COVID-19 disease and propose a model to explain potential factors contributing to post-COVID-19 fatigue. According to our model, fatigue is dependent on conditional and physiological factors. Conditional dependency comprises the task, environment, and physical and mental capacity of individuals, while physiological factors include central, psychological, and peripheral aspects. This model provides a framework for clinicians and researchers. However, future research is needed to validate our proposed model and elucidate all mechanisms of fatigue due to COVID-19. View Full-Text
Keywords: fatigue; COVID-19; recovery fatigue; COVID-19; recovery
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MDPI and ACS Style

Rudroff, T.; Fietsam, A.C.; Deters, J.R.; Bryant, A.D.; Kamholz, J. Post-COVID-19 Fatigue: Potential Contributing Factors. Brain Sci. 2020, 10, 1012.

AMA Style

Rudroff T, Fietsam AC, Deters JR, Bryant AD, Kamholz J. Post-COVID-19 Fatigue: Potential Contributing Factors. Brain Sciences. 2020; 10(12):1012.

Chicago/Turabian Style

Rudroff, Thorsten, Alexandra C. Fietsam, Justin R. Deters, Andrew D. Bryant, and John Kamholz. 2020. "Post-COVID-19 Fatigue: Potential Contributing Factors" Brain Sciences 10, no. 12: 1012.

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