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Appl. Sci. 2018, 8(7), 1143;

A High-Efficiency Super-Resolution Reconstruction Method for Ultrasound Microvascular Imaging

Department of Electronic Engineering, Fudan University, Shanghai 200433, China
Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Fudan University, Shanghai 200032, China
Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai 200030, China
Author to whom correspondence should be addressed.
Received: 17 June 2018 / Revised: 5 July 2018 / Accepted: 5 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue Ultrasound B-mode Imaging: Beamforming and Image Formation Techniques)
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The emergence of super-resolution imaging makes it possible to display the microvasculatures clearly using ultrasound imaging, which is of great importance in the early diagnosis of cancer. At present, the super-resolution performance can only be achieved when the sampling signal is long enough (usually more than 10,000 frames). Thus, the imaging time resolution is not suitable for clinical use. In this paper, we proposed a novel super-resolution reconstruction method, which is proved to have a satisfactory resolution using shorter sampling signal sequences. In the microbubble localization step, the integrated form of the 2D Gaussian function is innovatively adopted for image deconvolution in our method, which enhances the accuracy of microbubble positioning. In the trajectory tracking step, for the first time the averaged shifted histogram technique is presented for the visualization, which greatly improves the precision of reconstruction. In vivo experiments on rabbits were conducted to verify the effectiveness of the proposed method. Compared to the conventional reconstruction method, our method significantly reduces the Full-Width-at-Half-Maximum (FWHM) by 50% using only 400-frame signals. Besides, there is no significant increase in the running time using the proposed method. Considering its imaging performance and used frame number, the conclusion can be drawn that the proposed method advances the application of super-resolution imaging to the clinical use with a much higher time resolution. View Full-Text
Keywords: ultrasound imaging; super-resolution; microbubble; reconstruction; time resolution ultrasound imaging; super-resolution; microbubble; reconstruction; time resolution

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Guo, W.; Tong, Y.; Huang, Y.; Wang, Y.; Yu, J. A High-Efficiency Super-Resolution Reconstruction Method for Ultrasound Microvascular Imaging. Appl. Sci. 2018, 8, 1143.

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