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Appl. Sci. 2018, 8(6), 963; https://doi.org/10.3390/app8060963

Antimicrobial Effect of Titanium Hydroxyapatite in Denture Base Resin

1
Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata 573-1144, Japan
2
Department of Microbiology, School of Dentistry, Aichi Gakuin University, Nagoya 464-8650, Japan
*
Author to whom correspondence should be addressed.
Received: 15 May 2018 / Revised: 30 May 2018 / Accepted: 9 June 2018 / Published: 12 June 2018
(This article belongs to the Section Applied Biosciences and Bioengineering)
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Abstract

In the current study, we investigated the antimicrobial effect of titanium hydroxyapatite (TiHA), a photo-oxidizing organic material, in denture base resin on single-species biofilms formed by laboratory bacteria and on multispecies biofilms formed by bacteria from the human saliva. Although TiHA reportedly restricts the growth of planktonic bacteria upon ultraviolet A (UVA) irradiation, the antimicrobial effect of TiHA on bacterial biofilms remains to be elucidated. Resin specimens were prepared by adding TiHA to polymethyl methacrylate-based, denture base resin. The specimens were incubated with biofilm-forming Streptococcus sanguinis, Actinomyces naeslundii, Staphylococcus aureus, Escherichia coli, or bacteria from the human saliva obtained from volunteers. After UVA irradiation, the colony-forming units (CFUs) from the biofilms formed on the specimens were determined. CFU numbers for S. sanguinis, A. naeslundii, and S. aureus that formed biofilms on TiHA-containing specimens were significantly lower than those formed on specimens without TiHA. TiHA did not reduce the CFUs of biofilm-forming E. coli. In all cases, CFU numbers in the biofilms formed on TiHA-containing specimens by the salivary bacteria were significantly reduced. In addition, neither a 56 h UVA irradiation nor a 28 d soaking in water diminished the antibacterial effect of TiHA. TiHA in denture base resin exerts an antimicrobial effect on single-species bacterial biofilms and biofilms formed by a wide variety of bacteria from human saliva. View Full-Text
Keywords: titanium hydroxyapatite; photocatalyst; bacterial biofilms; antimicrobial effect; denture titanium hydroxyapatite; photocatalyst; bacterial biofilms; antimicrobial effect; denture
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Sato, W.; Yoshida, Y.; Komasa, S.; Hasegawa, Y.; Okazaki, J. Antimicrobial Effect of Titanium Hydroxyapatite in Denture Base Resin. Appl. Sci. 2018, 8, 963.

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