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Appl. Sci. 2016, 6(1), 8;

Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Collaborative Innovation Center of Chemical Science and Engineering, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
Authors to whom correspondence should be addressed.
Academic Editor: Helmut Martin Hügel
Received: 1 November 2015 / Revised: 16 December 2015 / Accepted: 17 December 2015 / Published: 4 January 2016
Full-Text   |   PDF [1382 KB, uploaded 4 January 2016]   |  


A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido substituted thiazole containing the 2-chlorophenyl group on the two position of the heterocyclic ring. Other structurally similar compounds displayed moderate activity. The key intermediates have been fully characterized. View Full-Text
Keywords: thiazole; amide; synthesis; antitumour thiazole; amide; synthesis; antitumour

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Cai, W.-X.; Liu, A.-L.; Li, Z.-M.; Dong, W.-L.; Liu, X.-H.; Sun, N.-B. Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives. Appl. Sci. 2016, 6, 8.

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