Next Article in Journal
A Novel Tunable Multi-Frequency Hybrid Vibration Energy Harvester Using Piezoelectric and Electromagnetic Conversion Mechanisms
Previous Article in Journal
Coordinated Volt/Var Control in Distribution Systems with Distributed Generations Based on Joint Active and Reactive Powers Dispatch
Open AccessArticle

Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Collaborative Innovation Center of Chemical Science and Engineering, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
Authors to whom correspondence should be addressed.
Academic Editor: Helmut Martin Hügel
Appl. Sci. 2016, 6(1), 8;
Received: 1 November 2015 / Revised: 16 December 2015 / Accepted: 17 December 2015 / Published: 4 January 2016
A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido substituted thiazole containing the 2-chlorophenyl group on the two position of the heterocyclic ring. Other structurally similar compounds displayed moderate activity. The key intermediates have been fully characterized. View Full-Text
Keywords: thiazole; amide; synthesis; antitumour thiazole; amide; synthesis; antitumour
Show Figures

Figure 1

MDPI and ACS Style

Cai, W.-X.; Liu, A.-L.; Li, Z.-M.; Dong, W.-L.; Liu, X.-H.; Sun, N.-B. Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives. Appl. Sci. 2016, 6, 8.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop