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Open AccessArticle

Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives

1
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
2
National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
3
Collaborative Innovation Center of Chemical Science and Engineering, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
4
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
5
College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Helmut Martin Hügel
Appl. Sci. 2016, 6(1), 8; https://doi.org/10.3390/app6010008
Received: 1 November 2015 / Revised: 16 December 2015 / Accepted: 17 December 2015 / Published: 4 January 2016
A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido substituted thiazole containing the 2-chlorophenyl group on the two position of the heterocyclic ring. Other structurally similar compounds displayed moderate activity. The key intermediates have been fully characterized. View Full-Text
Keywords: thiazole; amide; synthesis; antitumour thiazole; amide; synthesis; antitumour
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MDPI and ACS Style

Cai, W.-X.; Liu, A.-L.; Li, Z.-M.; Dong, W.-L.; Liu, X.-H.; Sun, N.-B. Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives. Appl. Sci. 2016, 6, 8.

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