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Appl. Sci. 2012, 2(2), 277-302;

Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges

Department of Nuclear Medicine, University Hospital Munich, Ludwig-Maximilians University Munich, Marchioninistr. 15, 81377 Munich, Germany
McConnell Brain Imaging Centre, McGill University, 3801 University Street, H3A 2B4 Montreal QC, Canada
Department of Molecular Imaging and Radiochemistry, University Hospital Mannheim, Institute for Clinical Radiology and Nuclear Medicine, Ruprecht Karls-University Heidelberg, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany
Authors to whom correspondence should be addressed.
Received: 9 February 2012 / Revised: 8 March 2012 / Accepted: 19 March 2012 / Published: 28 March 2012
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
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Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies are driven by the demand for more convenient 18F-labeling procedures to further disseminate one of the most sophisticated imaging technologies, Positron Emission Tomography (PET). The PET methodology requires special radionuclides such as 18F (one of the most prominent examples) to be introduced into bioactive molecules. Si-18F radiochemistry contributed greatly towards the development of new radiopharmaceuticals for PET imaging. Herein, we describe the radiochemical basics of Si-18F bond formation, the application of Si-18F tracers for PET imaging, and additionally, the inherent chemical intricacies of this methodology. View Full-Text
Keywords: fluorine-18; silicon; positron emission tomography (PET) fluorine-18; silicon; positron emission tomography (PET)

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Wängler, C.; Kostikov, A.; Zhu, J.; Chin, J.; Wängler, B.; Schirrmacher, R. Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges. Appl. Sci. 2012, 2, 277-302.

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