Next Article in Journal
Pedestrian-Crossing Detection Enhanced by CyclicGAN-Based Loop Learning and Automatic Labeling
Previous Article in Journal
Towards Geodetic Datum Modernization: A Comparative Study of GNSS Solutions in KGD2002 Using GAMIT/GLOBK and Bernese
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Applied Sciences
Volume 15
Issue 12
10.3390/app15126456
applsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients

by
José Manuel Rubín
1,2,
Lorena Suárez
2,3,4,
Begoña Cantabrana
2,3,4,
Eva Barreiro-Alonso
2,4,5,
Ignacio Rodríguez-Uña
6 and
Manuel Sánchez
2,3,4,*
1
Servicio de Cardiología, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain
2
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
3
Farmacología, Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
4
Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain
5
Servicio de Digestivo, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain
6
Instituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica (FIO), 33012 Oviedo, Spain
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(12), 6456; https://doi.org/10.3390/app15126456 (registering DOI)
Submission received: 3 May 2025 / Revised: 4 June 2025 / Accepted: 6 June 2025 / Published: 8 June 2025
(This article belongs to the Section Applied Biosciences and Bioengineering)
Versions Notes

Abstract

Polyamines are essential biological compounds that play crucial roles in various physiological processes, including cardiovascular function. This study explored polyamine levels in peripheral blood cells and plasma from patients with acute myocardial infarction (AMI) and chronic heart failure (CHF), aiming to assess their value as biomarkers for cardiac diseases. A total of 129 individuals participated, comprising healthy controls and patients diagnosed with AMI or CHF. Polyamine concentrations were measured and analysed alongside standard clinical and biochemical markers of cardiac diseases. The results showed distinct patterns of polyamine alteration in AMI patients; putrescine levels were reduced in mononuclear cells, while isoamylamine levels were elevated in erythrocytes and plasma. In contrast, CHF patients had consistently low levels of all measured polyamines in erythrocytes and plasma, accompanied by high isoamylamine levels. Statistical analyses revealed significant correlations between polyamine levels and clinical indicators such as left ventricular ejection fraction, diastolic blood pressure, and troponin. Discriminant function analysis effectively distinguished between the control, AMI, and CHF groups based on their polyamine profiles. These findings suggest that an altered polyamine metabolism is associated with cardiovascular disease and support the potential of blood polyamine profiling as a non-invasive diagnostic and monitoring tool. Further research is warranted.
Keywords: polyamines; putrescine; spermidine; spermine; isoamylamine; acute coronary syndrome; chronic heart failure polyamines; putrescine; spermidine; spermine; isoamylamine; acute coronary syndrome; chronic heart failure

Share and Cite

MDPI and ACS Style

Rubín, J.M.; Suárez, L.; Cantabrana, B.; Barreiro-Alonso, E.; Rodríguez-Uña, I.; Sánchez, M. Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients. Appl. Sci. 2025, 15, 6456. https://doi.org/10.3390/app15126456

AMA Style

Rubín JM, Suárez L, Cantabrana B, Barreiro-Alonso E, Rodríguez-Uña I, Sánchez M. Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients. Applied Sciences. 2025; 15(12):6456. https://doi.org/10.3390/app15126456

Chicago/Turabian Style

Rubín, José Manuel, Lorena Suárez, Begoña Cantabrana, Eva Barreiro-Alonso, Ignacio Rodríguez-Uña, and Manuel Sánchez. 2025. "Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients" Applied Sciences 15, no. 12: 6456. https://doi.org/10.3390/app15126456

APA Style

Rubín, J. M., Suárez, L., Cantabrana, B., Barreiro-Alonso, E., Rodríguez-Uña, I., & Sánchez, M. (2025). Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients. Applied Sciences, 15(12), 6456. https://doi.org/10.3390/app15126456

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop