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Volume 12
Issue 18
10.3390/app12188990
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Review

An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives

by
Ankit Srivastava
1,
Deeksha Rikhari
1,
Biswajita Pradhan
2,3,
Kaushik Kumar Bharadwaj
4,
Antonio Gaballo
5,
Alessandra Quarta
5,
Mrutyunjay Jena
2,
Sameer Srivastava
1,* and
Andrea Ragusa
5,6,*
1
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, India
2
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India
3
Department of Biotechnology, Sangmyung University, Seoul 03016, Korea
4
Department of Bioengineering and Technology, Guwahati University, Guwahati 781014, India
5
CNR-Nanotec, Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy
6
Department of Biological and Environmental Sciences and Technologies, Campus Ecotekne, University of Salento, Via Monteroni, 73100 Lecce, Italy
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2022, 12(18), 8990; https://doi.org/10.3390/app12188990
Submission received: 14 July 2022 / Revised: 4 September 2022 / Accepted: 5 September 2022 / Published: 7 September 2022
(This article belongs to the Special Issue Advances in Neuropeptide Biology)
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Abstract

Neuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due to the lack of selectivity toward the target cell, drug-resistance, and side-effects, thus pushing for the development of new therapeutic agents and therapies. Recent research suggests that neuropeptides influence cancer cell proliferation, invasion, metastasis, and angiogenesis and, therefore, they could be exploited as a target for novel anticancer therapies. Very recently, targeted approaches that inhibit neuropeptides and their associated receptors are being developed in cancer treatment. This review focuses on various neuropeptides and their potential utility as drug targets by different inhibitors as a recently identified approach to cancer prevention, with particular emphasis on colorectal cancer.
Keywords: neuropeptide; receptor; inhibitors; cancer; therapeutic agents; bombesin; neurotensin; vasoactive intestinal peptide; substance P neuropeptide; receptor; inhibitors; cancer; therapeutic agents; bombesin; neurotensin; vasoactive intestinal peptide; substance P

Share and Cite

MDPI and ACS Style

Srivastava, A.; Rikhari, D.; Pradhan, B.; Bharadwaj, K.K.; Gaballo, A.; Quarta, A.; Jena, M.; Srivastava, S.; Ragusa, A. An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives. Appl. Sci. 2022, 12, 8990. https://doi.org/10.3390/app12188990

AMA Style

Srivastava A, Rikhari D, Pradhan B, Bharadwaj KK, Gaballo A, Quarta A, Jena M, Srivastava S, Ragusa A. An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives. Applied Sciences. 2022; 12(18):8990. https://doi.org/10.3390/app12188990

Chicago/Turabian Style

Srivastava, Ankit, Deeksha Rikhari, Biswajita Pradhan, Kaushik Kumar Bharadwaj, Antonio Gaballo, Alessandra Quarta, Mrutyunjay Jena, Sameer Srivastava, and Andrea Ragusa. 2022. "An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives" Applied Sciences 12, no. 18: 8990. https://doi.org/10.3390/app12188990

APA Style

Srivastava, A., Rikhari, D., Pradhan, B., Bharadwaj, K. K., Gaballo, A., Quarta, A., Jena, M., Srivastava, S., & Ragusa, A. (2022). An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives. Applied Sciences, 12(18), 8990. https://doi.org/10.3390/app12188990

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