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Article

Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients

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Faculty of Health Sciences, University of Novo Mesto, 8000 Novo Mesto, Slovenia
2
Artros Center for Orthopaedic Surgery and Sports Medicine, 1000 Ljubljana, Slovenia
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Institute for Celular Regenerative Medicine, 1000 Ljubljana, Slovenia
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Orthopaedic Engineering & Sports Medicine Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15203, USA
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Educell, Cell Therapy Company, Prevale 9, 1236 Trzin, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editor: Hanatsu Nagano
Appl. Sci. 2021, 11(7), 2932; https://doi.org/10.3390/app11072932
Received: 27 February 2021 / Revised: 20 March 2021 / Accepted: 22 March 2021 / Published: 25 March 2021
(This article belongs to the Special Issue Biomechanical and Biomedical Factors of Knee Osteoarthritis)
The aim of this study was to evaluate and compare the effectiveness of three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) and bone marrow aspirate concentrate (BMAC) for the treatment of knee osteoarthritis (OA). A Level III retrospective comparative clinical study was performed on 505 consecutive patients treated with HA (n = 171), ACS (n = 222) or BMAC (n = 112) for knee OA. The mean patient age was 52 ± 13 years; 54.5% were males. Collected data included patient demographics, symptoms, visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and radiographic classification of osteoarthritis grade using plain radiographs and advanced imaging. Clinical outcome was assessed at 3 and 12 months post treatment. Significant improvement in VAS and WOMAC was seen for all three treatments at the 3-month follow-up. At 12 months, VAS was improved in all three treatment groups, yet only BMAC sustained the improved WOMAC even in patients with more severe degenerative changes. This study shows that BMAC is more effective than HA and ACS in the treatment of symptomatic knee OA, especially in the patients with more severe degenerative changes. View Full-Text
Keywords: osteoarthritis; knee; hyaluronic acid; autologous conditioned serum; bone marrow aspirate concentrate; clinical outcome osteoarthritis; knee; hyaluronic acid; autologous conditioned serum; bone marrow aspirate concentrate; clinical outcome
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MDPI and ACS Style

Hussein, M.; van Eck, C.F.; Kregar Velikonja, N. Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients. Appl. Sci. 2021, 11, 2932. https://doi.org/10.3390/app11072932

AMA Style

Hussein M, van Eck CF, Kregar Velikonja N. Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients. Applied Sciences. 2021; 11(7):2932. https://doi.org/10.3390/app11072932

Chicago/Turabian Style

Hussein, Mohsen, Carola F. van Eck, and Nevenka Kregar Velikonja. 2021. "Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients" Applied Sciences 11, no. 7: 2932. https://doi.org/10.3390/app11072932

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