The Recent Development of the Surgical Treatment for Hepatocellular Carcinoma

Round 1

Reviewer 1 Report

This manuscript is a review of the recent development of surgical treatment for HCC. Although this review is relatively short, the authors provide beneficial information by describing recent studies' results. However, there is content that needs to be supplemented or revised in a few areas before publication.

 

1. Most of the research results cited by the authors are biased towards specific research results in a specific country. Although the study is the largest and most recent, there is still much controversy on this subject. Therefore, it would be helpful to readers to introduce various studies in Eastern and Western countries and meta-analysis results as much as possible. Systemic review papers using meta-analysis have already been reported for some issues.

 

2. There are not many studies on surgical treatment in HCC with IVCTT patients. So far, there is insufficient evidence for the authors to recommend surgical treatment strongly. Until this part is verified through additional research results, it is considered that the level of recommendation needs to be modified.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

This review summarizes recent development of the surgical treatment for HCC. 

Comments

1. Development of staged resection, for example, ALPPS, should be discussed, along with strategies to increase resectabilitiy (portal vein embolization)
2. Surgical management of recurrent HCC should be discussed, for example, the role of re-resection, resection after liver transplantation.

Author Response

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Author Response File: Author Response.docx

Reviewer 3 Report

Dr. Nakajima and colleagues from Ube, Japan present a very interesting review of the literature and comprehensive description of the main difference of HCC management across the world (mainly Asian vs Western country). They outline the criteria for selecting treatment methods
for HCC patients and the panel of available treatments focused on the surgery. They advocate for the development of more international consensus treatment guidelines with more uniformity and flexibility.  

The authors should be congratulated for an excellent review and a carefully conducted analysis of the literature on an important topic. Here are a couple of comments aiming to improve the manuscript further:

 

Major:

• A methodological aspect of your literature review would be useful for the reader to understand your process of the literature analysis. Which keywords? databases? references manager software? etc.

Minor: 

• small typo to correct, line 262
• last line of your references no 88, you may delete the text that is not related to your reference.

 

Again, I enjoyed reading this excellent and important manuscript!

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

I think it is suitable for publication because the authors have made appropriate corrections to the comments.