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Volume 11
Issue 24
10.3390/app112411913
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Editorial

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

by
Benjamin Gantenbein
1,2
1
Tissue Engineering for Orthopaedics & Mechanobiology (TOM), Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, CH-3008 Bern, Switzerland
2
Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland
Appl. Sci. 2021, 11(24), 11913; https://doi.org/10.3390/app112411913
Submission received: 8 December 2021 / Accepted: 13 December 2021 / Published: 15 December 2021
(This article belongs to the Special Issue Intervertebral Disc Regeneration)
Versions Notes

Abstract

This Special Issue on intervertebral disc (IVD) regeneration focuses on novel advances in understanding the cell sources and culture conditions of various cell types, i.e., progenitor and IVD cells. The issue consists of seven articles that provide a comprehensive overview of recently applied research insights: (1) into how IVD herniation can be provoked in a controlled in vitro biomechanical testing set-up, (2) how cells can be used for IVD repair, (3) the physiological conditions of IVD cells and (4) how hyaluronic acid could be used for IVD repair, and (5) how nucleus pulposus progenitor cells (NPPCs) and mesenchymal stromal cells (MSCs) shall be cultured and expanded towards a possible cell therapy.
Keywords: biomaterials; tissue engineering; progenitor cells; cell therapy; biomechanics; lumbar disc herniation; GDF5; GDF6; TGFβ; nucleus pulposus progenitor cells (NPPC); losartanon biomaterials; tissue engineering; progenitor cells; cell therapy; biomechanics; lumbar disc herniation; GDF5; GDF6; TGFβ; nucleus pulposus progenitor cells (NPPC); losartanon

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MDPI and ACS Style

Gantenbein, B. New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials. Appl. Sci. 2021, 11, 11913. https://doi.org/10.3390/app112411913

AMA Style

Gantenbein B. New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials. Applied Sciences. 2021; 11(24):11913. https://doi.org/10.3390/app112411913

Chicago/Turabian Style

Gantenbein, Benjamin. 2021. "New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials" Applied Sciences 11, no. 24: 11913. https://doi.org/10.3390/app112411913

APA Style

Gantenbein, B. (2021). New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials. Applied Sciences, 11(24), 11913. https://doi.org/10.3390/app112411913

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