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Open AccessArticle

Morphological Changes in H1299 Human Lung Cancer Cells Following W-Band Millimeter-Wave Irradiation

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Department of Physics, Ariel University, Ariel 40700, Israel
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Department of Molecular Biology, Ariel University, Ariel 40700, Israel
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Department of Electrical & Electronic Engineering, Ariel University, Ariel 40700, Israel
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Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(9), 3187; https://doi.org/10.3390/app10093187
Received: 26 March 2020 / Revised: 22 April 2020 / Accepted: 29 April 2020 / Published: 2 May 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
Efficiently targeted cancer therapy without causing detrimental side effects is necessary for alleviating patient care and improving survival rates. This paper presents observations of morphological changes in H1299 human lung cancer cells following W-band millimeter wave (MMW) irradiation (75–105 GHz) at a non-thermal power density of 0.2 mW/cm2, investigated over 14 days of subsequent physiological incubation following exposure. Microscopic analyses of the physical parameters measured indicate MMW irradiation induces significant morphological changes characteristic of apoptosis and senescence. The immediate short-term responses translate into long-term effects, retained over the duration of the experiment(s), reminiscent of the phenomenon of accelerated cellular senescence (ACS), and achieving terminal tumorigenic cell growth. Further, results were observed to be treatment specific in an energy (dose)-dependent manner and were achieved without the use of chemotherapeutic agents, ionizing radiation, or thermal ablation employed in conventional methods, thereby overcoming the associated side effects. Adaptation of the experimental parameters of this study for clinical oncology concomitant with current developmental trends of non-invasive medical endoscopy alleviates MMW therapy as an effective treatment procedure for human non-small cell lung cancer (NSCLC). View Full-Text
Keywords: non-ionizing radiation; lung cancer; millimeter waves; cell morphology; 75–110 GHz non-ionizing radiation; lung cancer; millimeter waves; cell morphology; 75–110 GHz
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Komoshvili, K.; Becker, T.; Levitan, J.; Yahalom, A.; Barbora, A.; Liberman-Aronov, S. Morphological Changes in H1299 Human Lung Cancer Cells Following W-Band Millimeter-Wave Irradiation. Appl. Sci. 2020, 10, 3187.

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