A Systematic Overview of Recent Methods for Non-Contact Chronic Wound Analysis
Abstract
:1. Introduction
1.1. Brief Historical Overview
1.2. Methodology
2. Performance Metrics and Algorithms Overview
3. Image Acquisition, Preprocessing, and Postprocessing
- Conversion of color spacesImages captured by a camera or smartphone are typically saved in RGB color space which is not an ideal color space for analyzing color features. Two visually close colors for the human eye may be more separated in the color space than two other colors that are visually more distant [47]. Most of the considered research convert to some of the following color spaces:
- ▪
- HSV or HIS
- ▪
- YCbCrLuminosity component and blue-difference and red-difference chroma components. Li et al. [51] concluded that there is a clear difference between the skin and the background in the Cr channel.
- ▪
- YDbDr
- ▪
- CIELab
- ▪
- RYKWRed-Yellow-Black color space for determining the tissue types used in [55].
- ▪
- L*u*v* also called CIELUVColor space that attempts perceptual uniformity, defined by the CIE as a transformation of the 1931 CIE XYZ color space, used by [56].
- ▪
- Grayscale
- Choosing the right color channel for further analysisResearchers always take the most convenient channel from color space to achieve the best performance in the proposed method. Some of the used channels are:
- Noise removal and image blurringImage denoising is an important task in digital image analysis as its role is removing white and black pixels from the image caused by shadows, camera flash, etc. while preserving the edges. In the blurring of an image, the aim is to remove drastic changes in pixel values which usually occur on border pixels so the border becomes fuzzy. Chakraborty and Gupta [61] tested 16 different filters for noise removal and concluded that the best one is an adaptive median filter. Some of the other filters used in papers of wound analysis:
- Image croppingIn Shenoy et al. [44] authors resized images to fit the input of their CNN architecture, while Zhao et al. [65] segmented the target wound region with an annotation app. This was because if original images were fed into the network, it would learn most of the features of the background and therefore would not accurately learn wound features.
- Superpixel segmentation
- Color correction
- Color homogenization
- Contrast equalizationThe aim is to enhance contrast in the image to bring out subtle differences, usually done with contrast limited adaptive histogram equalization (CLAHE) as in [44].
4. Wound Segmentation
5. Tissue Classification
6. 3D Wound Reconstruction
7. Wound Measurement and Healing Prediction
8. Discussion
9. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Chronic Wounds, Overview and Treatment. Available online: https://www.woundsource.com/patientcondition/chronic-wounds (accessed on 13 July 2020).
- Dadkhah, A.; Pang, X.; Solis, E.; Fang, R.; Godavarty, A. Wound size measurement of lower extremity ulcers using segmentation algorithms. In Proceedings of the Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, San Francisco, CA, USA, 15–17 February 2016; Volume 9703, p. 97031D. [Google Scholar]
- Mukherjee, R.; Manohar, D.D.; Das, D.K.; Achar, A.; Mitra, A.; Chakraborty, C. Automated tissue classification framework for reproducible chronic wound assessment. BioMed Res. Int. 2014, 2014, 851582. [Google Scholar] [CrossRef] [Green Version]
- Gautam, G.; Mukhopadhyay, S. Efficient contrast enchancement based on local–global image statistics and multiscale morphological filtering. Adv. Comput. Commun. Paradig. 2017, 2, 229–238. [Google Scholar]
- Biswas, T.; Ahmad Fauzi, M.F.; Abas, F.S.; Logeswaran, R.; Nair, H.K.R. Wound Area Segmentation Using 4-D Probability Map and Superpixel Region Growing. In Proceedings of the 2019 IEEE International Conference on Signal and Image Processing Applications (ICSIPA), Kuala Lampur, Malaysia, 17–19 September 2019; pp. 29–34. [Google Scholar]
- Mukherjee, R.; Tewary, S.; Routray, A. Diagnostic and prognostic utility of non-invasive multimodal imaging in chronic wound monitoring: A systematic review. J. Med. Syst. 2017, 41, 46. [Google Scholar] [CrossRef] [PubMed]
- Chakraborty, C. Chronic wound image analysis by particle swarm optimization technique for tele-wound network. Wirel. Person. Commun. 2017, 96, 3655–3671. [Google Scholar] [CrossRef]
- Manohar Dhane, D.; Maity, M.; Mungle, T.; Bar, C.; Achar, A.; Kolekar, M.; Chakraborty, C. Fuzzy spectral clustering for automated delineation of chronic wound region using digital images. Comput. Biol. Med. 2017, 89, 551–560. [Google Scholar] [CrossRef] [PubMed]
- Maity, M.; Dhane, D.; Bar, C.; Chakraborty, C.; Chatterjee, J. Pixel-based supervised tissue classification of chronic wound images with deep autoencoder. Adv. Comput. Commun. Paradig. 2017, 2, 727–735. [Google Scholar]
- Zahia, S.; Garcia Zapirain, M.B.; Sevillano, X.; González, A.; Kim, P.J.; Elmaghraby, A. Pressure injury image analysis with machine learning techniques: A systematic review on previous and possible future methods. Artif. Intell. Med. 2020, 102, 101742. [Google Scholar] [CrossRef] [PubMed]
- Chakraborty, C. Computational approach for chronic wound tissue characterization. Inform. Med. Unlocked 2019, 17, 100162. [Google Scholar] [CrossRef]
- Rajathi, V.; Bhavani, R.R.; Wiselin Jiji, G. Varicose ulcer (C6) wound image tissue classification using multidimensional convolutional neural networks. Imaging Sci. J. 2019, 67, 374–384. [Google Scholar] [CrossRef]
- Kumar, K.S.; Reddy, B.E. Wound image analysis classifier for efficient tracking of wound healing status. Sign. Image Process. Int. J. 2014, 5, 15–27. [Google Scholar]
- Chang, A.C.; Dearman, B.; Greenwood, J.E. A comparison of wound area measurement techniques: Visitrak versus photography. Eplasty 2011, 11, 158–166. [Google Scholar]
- Medical Device Technical Consultancy Service. Pictures of Wounds and Surgical Wound Dressings. Available online: http://www.medetec.co.uk/files/medetec-image-databases.html (accessed on 14 July 2020).
- Lu, H.; Li, B.; Zhu, J.; Li, Y.; Li, Y.; Xu, X.; He, L.; Li, X.; Li, J.R.; Serikawa, S. Wound intensity correction and segmentation with convolutional neural networks. Concurr. Comput. Pract. Exp. 2016, 22, 685–701. [Google Scholar] [CrossRef]
- Musen, M.A.; Middleton, B.; Greenes, R.A. Clinical decision-support systems. In Biomedical Informatics Computer Applications in Health Care and Biomedicine, 4th ed.; Springer: London, UK, 2014. [Google Scholar]
- Garg, A.X.; Adhikari, N.K.J.; McDonald, H. Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: A systematic review. J. Am. Med. Assoc. 2005, 293, 1223–1238. [Google Scholar] [CrossRef]
- Langemo, D.K.; Melland, H.; Hanson, D.; Olson, B.; Hunter, S.; Henly, S.J. Two-dimensional wound measurement: Comparison of 4 techniques. Adv. Wound Care J. Prevent. Heal. 1998, 11, 337–343. [Google Scholar]
- Filko, D.; Davor, A.; Dubravko, H. WITA-Application for Wound Analysis and Management. In Proceedings of the International Conference on e-health Networking, Applications and Services (HealthCom), Lyon, France, 1–3 July 2010. [Google Scholar]
- Solomon, C.; Munro, A.R.; Van Rij, A.M.; Christie, R. The use of video image analysis for the measurement of venous ulcers. Br. J. Dermatol. 1995, 133, 565–570. [Google Scholar] [CrossRef]
- Schubert, V.; Zander, M. Analysis of the measurement of four wound variables in elderly patients with pressure ulcers. Adv. Wound Care J. Prevent. Health 1996, 9, 29–36. [Google Scholar]
- Smith, R.B.; Rogers, B.; Tolstykh, G.P.; Walsh, N.E.; Davis, M.G.; Bunegin, L.; Williams, R.L. Three-dimensional laser imaging system for measuring wound geometry. Lasers Surg. Med. 1998, 23, 87–93. [Google Scholar] [CrossRef]
- Plassmann, P.; Jones, T.D. MAVIS: A non-invasive instrument to measure area and volume of wounds. Med. Eng. Phys. 1998, 20, 332–338. [Google Scholar] [CrossRef]
- Mekkes, J.R.; Westerhof, W. Image processing in the study of wound healing. Clin. Dermatol. 1995, 13, 401–407. [Google Scholar] [CrossRef]
- Berriss, W.P.; Sangwine, S.J. A color histogram clustering technique for tissue analysis of healing skin wounds. In Proceedings of the 6th International Conference on Image Processing and Its Applications, Dublin, Ireland, 14–17 July 1997; pp. 693–697. [Google Scholar]
- Kolesnik, M.; Fexa, A. Segmentation of wounds in the combined color-texture feature space. In Proceedings of the Medical Imaging 2004: Image Processing, San Francisco, CA, USA, 14–19 February 2004; Volume 5370, p. 549. [Google Scholar]
- Sugama, J.; Matsui, Y.; Sanada, H.; Konya, C.; Okuwa, M.; Kitagawa, A. A study of the efficiency and convenience of an advanced portable Wound Measurement System (VISITRAKTM). J. Clin. Nurs. 2007, 16, 1265–1269. [Google Scholar] [CrossRef]
- Krouskop, T.A.; Baker, R.; Wilson, M.S. A noncontact wound measurement system. J. Rehabilit. Res. Dev. 2002, 39, 337–345. [Google Scholar]
- Plassmann, P.; Jones, C.D.; McCarthy, C. Accuracy and precision of the MAVIS-II wound measurement device. Wound Repair Regenerat. 2007, 15, A129. [Google Scholar]
- Treuillet, S.; Albouy, B.; Lucas, Y. Three-dimensional assessment of skin wounds using a standard digital camera. IEEE Trans. Med. Imaging 2009, 28, 752–762. [Google Scholar] [CrossRef] [PubMed]
- Filko, D.; Nyarko, E.K.; Cupec, R. Wound detection and reconstruction using RGB-D camera. In Proceedings of the 2016 39th International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO), Opatija, Croatia, 30 May–3 June 2016. [Google Scholar]
- García-Zapirain, B.; Elmogy, M.; El-Baz, A.; Elmaghraby, A.S. Classification of pressure ulcer tissues with 3D convolutional neural network. Med. Biol. Eng. Comput. 2018, 56, 2245–2258. [Google Scholar] [CrossRef] [PubMed]
- Wang, L.; Pedersen, P.C.; Strong, D.M.; Tulu, B.; Agu, E.; Ignotz, R. Smartphone-based wound assessment system for patients with diabetes. IEEE Trans. Biomed. Eng. 2015, 62, 477–488. [Google Scholar] [CrossRef] [PubMed]
- Taha, A.A.; Hanbury, A. Metrics for evaluating 3D medical image segmentation: Analysis, selection, and tool. BMC Med. Imaging 2015, 15, 29. [Google Scholar] [CrossRef] [Green Version]
- Ohura, N.; Mitsuno, R.; Sakisaka, M.; Terabe, Y.; Morishige, Y.; Uchiyama, A.; Okoshi, T.; Shinji, I.; Takushima, A. Convolutional neural networks for wound detection: The role of artificial intelligence in wound care. J. Wound Care 2019, 28, S13–S24. [Google Scholar] [CrossRef]
- Fauzi, M.F.A.; Khansa, I.; Catignani, K.; Gordillo, G.; Sen, C.K.; Gurcan, M.N. Segmentation and management of chronic wound images: A computer-based approach. Chronic Wounds Wound Dress. Wound Healing 2018, 6, 115–134. [Google Scholar]
- Sirazitdinova, E.; Deserno, T.M. System design for 3D wound imaging using low-cost mobile devices. In Proceedings of the Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications, San Francisco, CA, USA, 15–16 February 2017; Volume 10138, p. 1013810. [Google Scholar]
- Kumar, C.V.; Malathy, V. Image processing based wound assessment system for patients with diabetes using six classification algorithms. In Proceedings of the International Conference on Electrical, Electronics, and Optimization Techniques (ICEEOT), Chennai, India, 3–5 March 2016; pp. 744–747. [Google Scholar]
- Veredas, F.J.; Luque-Baena, R.M.; Martín-Santos, F.J.; Morilla-Herrera, J.C.; Morente, L. Wound image evaluation with machine learning. Neurocomputing 2015, 164, 112–122. [Google Scholar] [CrossRef]
- Zahia, S.; Sierra-Sosa, D.; García-Zapirain, B.; Elmaghraby, A. Tissue classification and segmentation of pressure injuries using convolutional neural networks. Comput. Methods Progr. Biomed. 2018, 159, 51–58. [Google Scholar] [CrossRef]
- Goyal, M.; Reeves, N.D.; Rajbhandari, S.; Spragg, J.; Yap, M.H. Fully convolutional networks for diabetic foot ulcer segmentation. In Proceedings of the 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC), Banff, AB, Canada, 5–8 October 2017; pp. 618–623. [Google Scholar]
- Elmogy, M.; García-Zapirain, B.; Burns, C.; Elmaghraby, A.; El-baz, A. Tissues Classification for Pressure Ulcer Images Based on 3D Convolutional Neural Network. In Proceedings of the 2018 25th IEE International Conference of Image Processing (ICIP), Athens, Greece, 7–10 October 2018. [Google Scholar]
- Shenoy, V.N.; Foster, E.; Aalami, L.; Majeed, B.; Aalami, O. Deepwound: Automated Postoperative Wound Assessment and Surgical Site Surveillance through Convolutional Neural Networks. In Proceedings of the 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Madrid, Spain, 3–6 December 2018; pp. 1017–1021. [Google Scholar]
- Nejati, H.; Ghazijahani, H.A.; Abdollahzadeh, M.; Malekzadeh, T.; Cheung, N.M.; Lee, K.H.; Low, L.L. Fine-Grained Wound Tissue Analysis Using Deep Neural Network. In Proceedings of the IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Calgary, AB, Canada, 15–20 April 2018; pp. 1010–1014. [Google Scholar]
- Wang, L.; Pedersen, P.C.; Agu, E.; Strong, D.M.; Tulu, B. Area determination of diabetic foot ulcer images using a cascaded two-stage svm-based classification. IEEE Trans. Biomed. Eng. 2017, 64, 2098–2109. [Google Scholar] [CrossRef] [PubMed]
- Vıtor, G.; Neto, J.S.; Carvalho, B.; Santana, B.; Ferraz, J.; Gama, R. Chronic Wound Tissue Classification Using Convolutional Neural Networks and Color Space Reduction. In Proceedings of the 2018 IEEE 28th International Workshop on Machine Learning for Signal Processing (MLSP), Aalborg, Denmark, 17–20 September 2018; pp. 2–7. [Google Scholar]
- Dhane, D.M.; Krishna, V.; Achar, A.; Bar, C.; Sanyal, K.; Chakraborty, C. Spectral clustering for unsupervised segmentation of lower extremity wound beds using optical images. J. Med. Syst. 2016, 40, 207. [Google Scholar] [CrossRef] [PubMed]
- Gupta, A. Real time wound segmentation/management using image processing on handheld devices. J. Comput. Methods Sci. Eng. 2017, 17, 321–329. [Google Scholar] [CrossRef]
- Dalya, V.; Shedge, D.K. Design of Smartphone-Based Wound Assessment System. In Proceedings of the 2016 International Conference on Automatic Control and Dynamic Optimization Techniques (ICACDOT), Pune, India, 9–10 September 2016; pp. 709–712. [Google Scholar]
- Li, F.; Wang, C.; Liu, X.; Peng, Y.; Jin, S. A Composite model of wound segmentation based on traditional methods and deep neural networks. Comput. Intell. Neurosci. 2018, 2018, 1–12. [Google Scholar] [CrossRef] [Green Version]
- Yadav, M.K.; Manohar, D.D.; Mukherjee, G.; Chakraborty, C. Segmentation of chronic wound areas by clustering techniques using selected color space. J. Med. Imaging Health Inform. 2013, 3, 22–29. [Google Scholar] [CrossRef]
- Haider, A.; Alhashim, M.; Tavakolian, K.; Fazel-Rezai, R. Computer-Assisted Image Processing Technique for Tracking Wound Progress. In Proceedings of the IEEE International Conference on Electro Information Technology, Grand Forks, NC, USA, 19–21 May 2016; pp. 750–754. [Google Scholar]
- Lee, H.; Lee, B.U.; Park, J.; Sun, W.; Oh, B.; Yang, S. Segmentation of Wounds Using Gradient Vector Flow. In Proceedings of the International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS), Okinawa, Japan, 28–30 November 2015; pp. 390–391. [Google Scholar]
- Wang, L.; Pedersen, P.C.; Strong, D.M.; Tulu, B.; Agu, E.; Ignotz, R.; He, Q. An automatic assessment system of diabetic foot ulcers based on wound area determination, color segmentation, and healing score evaluation. J. Diabet. Sci. Technol. 2016, 10, 421–428. [Google Scholar] [CrossRef]
- Veredas, F.J.; Mesa, H.; Morente, L. Efficient detection of wound-bed and peripheral skin with statistical colour models. Med. Biol. Eng. Comput. 2015, 53, 345–359. [Google Scholar] [CrossRef]
- David, O.P.; Sierra-Sosa, D.; García-Zapirain, B. Pressure ulcer image segmentation technique through synthetic frequencies generation and contrast variation using toroidal geometry. BioMed Eng. Online 2017, 16, 1–19. [Google Scholar]
- Biswas, T.; Ahmad Fauzi, M.F.; Abas, F.S.; Nair, H.K.R. Superpixel Classification with Color and Texture Features for Automated Wound Area Segmentation. In Proceedings of the 2018 IEEE 16th Student Conference on Research and Development (SCOReD), Selangor, Malaysia, 26–28 November 2018; pp. 1–6. [Google Scholar]
- Huang, C.H.; Jhan, S.; Da Lin, C.H.; Liu, W.M. Automatic Size Measurement and Boundary Tracing of Wound on a Mobile Device. In Proceedings of the 2018 IEEE International Conference on Consumer Electronics-Taiwan (ICCE-TW), Taichung, China, 19–21 May 2018; pp. 1–2. [Google Scholar]
- Navas, M.; Luque-Baena, R.M.; Morente, L.; Coronado, D.; Rodríguez, R.; Veredas, F.J. Computer-aided diagnosis in wound images with neural networks. Lect. Notes Comput. Sci. 2013, 7903, 439–448. [Google Scholar]
- Chakraborty, C.; Gupta, B. Adaptive filtering technique for chronic wound analysis under tele-wound network. J. Commun. Navig. Sens. Serv. 2016, 2016, 57–76. [Google Scholar] [CrossRef] [Green Version]
- İlkin, S.; Gülağız, F.K.; Hangişi, F.S.; Şahin, S. Computer aided wound area detection system for dermatological images. In Trends and Advances in Information Systems and Technologies, Proceedings of the WorldCIST18: World Conference on Information Systems and Technologies, Naples, Italy, 27–29 March 2018; Rocha, Á., Adeli, H., Reis, L., Costanzo, S., Eds.; Springer: Berlin/Heidelberg, Germany, 2018; p. 746. [Google Scholar]
- Kavitha, I.; Suganthi, S.S.; Ramakrishnan, S. Analysis of Chronic Wound Images Using Factorization Based Segmentation and Machine Learning Methods. In Proceedings of the ICCBB 2017 International Conference on Computational Biology and Bioinformatics, Newark, NJ, USA, 18–20 October 2017; pp. 74–78. [Google Scholar]
- Gholami, P.; Ahmadi-Pajouh, M.A.; Abolftahi, N.; Hamarneh, G.; Kayvanrad, M. Segmentation and measurement of chronic wounds for bioprinting. IEEE J. Biomed. Health Inform. 2018, 22, 1269–1277. [Google Scholar] [CrossRef] [PubMed]
- Zhao, X.; Liu, Z.; Agu, E.; Wagh, A.; Jain, S.; Lindsay, C.; Tulu, B.; Strong, D.; Kan, J. Fine-grained diabetic wound depth and granulation tissue amount assessment using bilinear convolutional neural network. IEEE Access 2019, 7, 179151–179162. [Google Scholar] [CrossRef]
- Liu, G.; Duan, J. RGB-D image segmentation using superpixel and multi-feature fusion graph theory. Signal Image Video Process. 2020, 14, 1171–1179. [Google Scholar] [CrossRef]
- Chakraborty, C. Performance analysis of compression techniques for chronic wound image transmission under smartphone-enabled tele-wound network. Int. J. E-Health Med. Commun. 2019, 10, 1–20. [Google Scholar] [CrossRef]
- Ahmad Fauzi, M.F.; Khansa, I.; Catignani, K.; Gordillo, G.; Sen, C.K.; Gurcan, M.N. Computerized segmentation and measurement of chronic wound images. Comput. Biol. Med. 2015, 60, 74–85. [Google Scholar] [CrossRef]
- Liu, X.; Wang, C.; Li, F.; Zhao, X.; Zhu, E.; Peng, Y. A framework of wound segmentation based on deep convolutional networks. In Proceedings of the 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI), Shanghai, China, 14–16 October 2017; pp. 1–7. [Google Scholar]
- Li, F.; Wang, C.; Peng, Y.; Yuan, Y.; Jin, S. Wound segmentation network based on location information enhancement. IEEE Access 2019, 7, 87223–87232. [Google Scholar] [CrossRef]
- Filko, D.; Cupec, R.; Nyarko, E.K. Wound measurement by RGB-D camera. Mach. Vis. Appl. 2018, 29, 633–654. [Google Scholar] [CrossRef]
- Wagh, A.; Jain, S.; Mukherjee, A.; Agu, E.; Pedersen, P.; Strong, D.; Tulu, B.; Lindsay, C.; Liu, Z. Semantic segmentation of smartphone wound images: Comparative analysis of AHRF and CNN-based approaches. IEEE Access 2020, 8, 181590–181604. [Google Scholar] [CrossRef]
- Wu, W.; Yong, K.Y.W.; Federico, M.A.J.; Gan, S.K.-E. The APD skin monitoring app for wound monitoring: Image processing, area plot, and colour histogram. Sci. Phone Apps Mob. Dev. 2019, 5, 1–9. [Google Scholar] [CrossRef]
- Cirillo, M.D.; Mirdell, R.; Sjöberg, F.; Pham, T.D. Tensor decomposition for colour image segmentation of burn wounds. Sci. Rep. 2019, 9, 1–13. [Google Scholar] [CrossRef] [Green Version]
- Cui, C.; Thurnhofer-Hemsi, K.; Soroushmehr, R.; Mishra, A.; Gryak, J.; Dominguez, E.; Najarian, K.; Lopez-Rubio, E. Diabetic Wound Segmentation using Convolutional Neural Networks. In Proceedings of the 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 23–27 July 2019; pp. 1002–1005. [Google Scholar]
- Şevik, U.; Karakullukçu, E.; Berber, T.; Akbaş, Y.; Türkyilmaz, S. Automatic classification of skin burn colour images using texture-based feature extraction. IET Image Process. 2019, 13, 2018–2028. [Google Scholar] [CrossRef]
- Farmaha, I.; Banaś, M.; Savchyn, V.; Lukashchuk, B.; Farmaha, T. Wound image segmentation using clustering based algorithms. New Trends Prod. Eng. 2019, 2, 570–578. [Google Scholar] [CrossRef] [Green Version]
- Bhavani, R.R.; Jiji, G.W. Image registration for varicose ulcer classification using KNN classifier. Int. J. Comput. Appl. 2018, 40, 88–97. [Google Scholar] [CrossRef]
- Yang, X.; Zeng, Z.; Yeo, S.Y.; Tan, C.; Tey, H.L.; Su, Y. A novel multi-task deep learning model for skin lesion segmentation and classification. arXiv 2017, arXiv:1703.01025v1. [Google Scholar]
- Babu, K.S.; Ravi Kumar, Y.B.; Sabut, S. An Improved Watershed Segmentation by Flooding and Pruning Algorithm for Assessment of Diabetic Wound Healing. In Proceedings of the 2nd IEEE International Conference on Recent Trends in Electronics, Information and Communication Technology (RTEICT), Bengaluru, India, 19–20 May 2017; pp. 679–683. [Google Scholar]
- Pasero, E.; Castagneri, C. Application of an Automatic Ulcer Segmentation Algorithm. In Proceedings of the IEEE 3rd International Forum on Research and Technologies for Society and Industry, Conference (RTSI), Modena, Italy, 11–13 September 2017; pp. 50–53. [Google Scholar]
- Demyanov, S.; Chakravorty, R.; Abedini, M.; Halpern, A.; Garnavi, R. Classification of Dermoscopy Patterns Using Deep Convolutional Neural Networks. In Proceedings of the IEEE 13th International Symposium on Biomedical Imaging (ISBI), Prague, Czech Republic, 13–16 April 2016; pp. 364–368. [Google Scholar]
- Khan, S.; Paul, S.; Rao, S.S.; Krishnareddy, A. Segmenting Skin Ulcers Based on Thresholding and Watershed Segmentation. In Proceedings of the 2015 International Conference on Communication and Signal Processing (ICCSP), Tamilnadu, India, 10–11 October 2015; pp. 1679–1683. [Google Scholar]
- Zhang, X.; Yang, L.; Wang, J.; Zhao, Q.; Qiao, A. The Design of Wound Area Measurement Software Based on Android Operating System. In Proceedings of the 11th World Congress on Intelligent Control and Automation (WCICA), Changsha, China, 4–8 July 2015; pp. 2946–2950. [Google Scholar]
- Wang, C.; Yan, X.; Smith, M.; Kochhar, K.; Rubin, M.; Warren, S.M.; Wrobel, J.; Lee, H. A Unified Framework for Automatic Wound Segmentation and Analysis with Deep Convolutional Neural Networks. In Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Milano, Italy, 25–29 August 2015; pp. 2415–2418. [Google Scholar]
- Nizam, K.; Ahmad Fauzi, M.F.; Ahmad, N.N.; Nair, H.K.R. Characterization of Tissues in Chronic Wound Images. In Proceedings of the 2018 IEEE 16th Student Conference on Research and Development (SCOReD), Selangor, Malaysia, 3–6 June 2018; pp. 26–30. [Google Scholar]
- Ahmad Fauzi, M.F.; Khansa, I.; Catignani, K.; Gordillo, G.; Sen, C.K.; Gurcan, M.N. Segmentation and automated measurement of chronic wound images: Probability map approach. Med. Imaging Comput. Aided Diagn. 2014, 9035, 903507. [Google Scholar]
- Chakraborty, C.; Gupta, B.; Ghosh, S.K. Chronic wound tissue characterization under telemedicine framework. In Proceedings of the 17th International Conference on E-Health Networking, Application and Services (HealthCom), Boston, MA, USA, 14–17 October 2015; pp. 569–573. [Google Scholar]
- Chakraborty, C.; Gupta, B.; Ghosh, S.K. Tele-wound technology network for assessment of chronic wounds. Int. J. Telemed. Clin. Pract. 2016, 1, 345. [Google Scholar] [CrossRef]
- Chakraborty, C.; Gupta, B.; Ghosh, S.K.; Das, D.K.; Chakraborty, C. Telemedicine supported chronic wound tissue prediction using classification approaches. J. Med. Syst. 2016, 40, 1–12. [Google Scholar] [CrossRef]
- Elmogy, M.; García-Zapirain, B.; Burns, C.; Elmaghraby, A.; Ei-Baz, A. An Automated Classification Framework for Pressure Ulcer Tissues Based on 3D Convolutional Neural Network. In Proceedings of the International Conference on Image Processing (ICIP), Athens, Greece, 7–10 October 2018; pp. 3139–3143. [Google Scholar]
- García-Zapirain, B.; Shalaby, A.; El-Baz, A.; Elmaghraby, A. Automated framework for accurate segmentation of pressure ulcer images. Comput. Biol. Med. 2017, 90, 137–145. [Google Scholar] [CrossRef]
- Garcia-Zapirain, B.; Sierra-Sosa, D.; Ortiz, D.; Isaza-Monsalve, M.; Elmaghraby, A. Efficient use of mobile devices for quantification of pressure injury images. Technol. Health Care 2018, 26, S269–S280. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Pholberdee, N.; Pathompatai, C.; Taeprasartsit, P. Study of Chronic Wound Image Segmentation: Impact of Tissue Type and Color Data Augmentation. In Proceedings of the 15th International Joint Conference on Computer Science and Software Engineering (JCSSE), Nakhonpathom, Thailand, 11–13 July 2018; pp. 1–6. [Google Scholar]
- Patel, S.; Patel, R.; Desai, D. Diabetic foot ulcer wound tissue detection and classification. In Proceedings of the International Conference on Innovations in Information, Embedded and Communication Systems (ICIIECS), Coimbatore, India, 17–18 March 2017; pp. 1–5. [Google Scholar]
- Callieri, M.; Cignoni, P.; Pingi, P.; Scopigno, R. Derma: Monitoring the Evolution of Skin Lesions with a 3D System. In Proceedings of the Vision, Modeling, and Visualization Conference, Muchen, Germany, 19–21 November 2003; pp. 167–174. [Google Scholar]
- Sprigle, S.; Nemeth, M.; Gajjala, A. Iterative design and testing of a hand-held, non-contact wound measurement device. J. Tissue Viability 2012, 21, 17–26. [Google Scholar] [CrossRef] [PubMed]
- Malian, A.; Azizi, A.; Van Den Heuvel, F.A.; Zolfaghari, M. Development of a robust photogrammetric metrology system for monitoring the healing of bedsores. Photogramm. Rec. 2005, 20, 241–273. [Google Scholar] [CrossRef]
- Filko, D.; Cupec, R.; Nyarko, E.K. Detection, reconstruction and segmentation of chronic wounds using kinect v2 sensor. Proc. Comput. Sci. 2016, 90, 151–156. [Google Scholar] [CrossRef] [Green Version]
- Wannous, H.; Lucas, Y.; Treuillet, S. Enhanced assessment of the wound-healing process by accurate multiview tissue classification. IEEE Trans. Med. Imaging 2011, 30, 315–326. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Marsh, K.M.; Anghel, E.L. Wound measurement, score. Vascular surgery, neurosurgery, lower extremity ulcers, antimicrobials, wound assessment, care, measurement and repair. In Recent Clinical Techniques, Results, and Research in Wounds; Springer: Berlin/Heidelberg, Germany, 2018; p. 5. [Google Scholar]
- Gaur, A.; Sunkara, R.; Raj, A.N.J.; Celik, T. Efficient wound measurements using RGB and depth images. Int. J. Biomed. Eng. Technol. 2015, 18, 333–358. [Google Scholar] [CrossRef]
- Barbosa, F.; Carvalho, B.; Gomes, R.B. Accurate Chronic Wound Area Measurement using Structure from Motion. In Proceedings of the IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS), Rochester, MN, USA, 22–24 July 2020; pp. 208–213. [Google Scholar]
- Shirley, T.; Presnov, D.; Kolb, A. A lightweight approach to 3D measurement of chronic wounds. J. WSCG 2019, 27, 67–74. [Google Scholar] [CrossRef]
- Shi, R.B.; Qiu, J.; Maida, V. Towards algorithm-enabled home wound monitoring with smartphone photography: A hue-saturation-value colour space thresholding technique for wound content tracking. Int. Wound J. 2018, 16, 211–218. [Google Scholar] [CrossRef] [Green Version]
- Khalil, A.; Elmogy, M.; Ghazal, M.; Burns, C.; El-Baz, A. Chronic wound healing assessment system based on different features modalities and non-negative matrix factorization (NMF) feature reduction. IEEE Access 2019, 7, 80110–80121. [Google Scholar] [CrossRef]
- Chang, M.C.; Yu, T.; Luo, J.; Duan, K.; Tu, P.; Zhao, Y.; Nagraj, N.; Rajiv, V.; Priebe, M.; Wood, E.A.; et al. Multimodal sensor system for pressure ulcer wound assessment and care. IEEE Trans. Ind. Inform. 2017, 14, 1186–1196. [Google Scholar] [CrossRef]
- Dan, L.; Carol, M. Automated measurement of pressure injury through image processing. Int. J. Lab. Hematol. 2017, 38, 42–49. [Google Scholar]
- Banchev, B. Wound size measurement and 3D reconstruction using structured light. Groundwork and analysis of requirements. Comput. Sci. Technol. 2014, 1, 114–121. [Google Scholar]
- Charles, R.; Qi, L.Y.; Hao, S.; Leonidas, J.G. PointNet++: Deep Hierarchical Feature Learning on Point Sets in a Metric Space. Comput. Vis. Pattern Recogn. 2017, 2017, 5105–5114. [Google Scholar]
Paper | Preprocessing | Segmentation | Image Database | Performance Metrics | Time (s) Avg/Min/Max |
---|---|---|---|---|---|
Wagh et al., [72] 2020. | CLAHE | CNN (FCN, U-Net, DeepLabV3 model), associative hierarchical random field (AHRF) | 1758 images (Personal + from Internet) | Dice Coefficient 0.876 | 0.049/0.04/300 |
Wu et al., [73] 2019. | N/A | GrabCut algorithm, color thresholding | 4 images | N/A | 1.7/1.47/2.23 |
Cirillo et al., [74] 2019. | CIELab color space, Gaussian filtering | Fuzzy c-mean clustering, Postprocessing: morphological operation | 13 images | Sensitivity 95.89% | 214.5/115/358 |
Cui et al., [75] 2019. | Noise removal (mean filter), color constancy | CNN—Patch-based and U-net model | 445 images | Accuracy 96.6% | N/A |
Şevik et al., [76] 2019. | CIELab color space, Fuzzy C-means (FCM), SLIC, k-means, expectation maximization (EM) | CNN—SegNet model, ANN | 105 images | Precision 79.98% | 505.1/18.48/1579.76 |
Farmaha et al., [77] 2019. | SLIC, Watershed, Quickshift superpixel segmentation | Autoencoder (DNN), Deep Embedded Clustering (DEC), k means | 150 images | N/A | 7.25/6.87/7.85 |
Li et al., [70] 2019. | Location map | DNN—MobileNet model | 950 images (Personal + Medetec) | Precision 95.02% | N/A |
Biswas et al., [5] 2019. | SLIC, HSV color space modification | 4D probability map, Superpixel region growing | 30 images | Accuracy 79.2% | 3/-/- |
Ohura et al., [36] 2019. | N/A | CNN—U-Net model | 396 images | Accuracy 97.8% | 7.09/-/- |
Gholami et al., [64] 2018. | Intensity normalization, Gaussian blur | Region growing, HTB, active contour, edge and morphological operations, level set, livewire, snakes, | 26 images | Accuracy 97.08% | 17.8/-/- |
X. Liu et al., [69] 2018. | Training data augmentation | DNN—MobileNet model | 950 images (Personal + Medetec) | Accuracy 98.18% | N/A |
Bhavani and Jiji [78] 2018. | Image differencing, image registration | Region growing, K-means, kNN | 1770 images | Accuracy 94.85% | N/A |
Huang et al., [59] 2018. | White balance, anti-glare-Otsu’s threshold method, CLAHE | Level set, snake | 1 image | N/A | N/A |
İlkin et al., [62] 2018. | Median filter | Otsu’s threshold method, Canny Edge algorithm | 170 images | N/A | 39.6/8.95/100.17 |
Li et al., [51] 2018. | YCbCr color space, Cr channel used | Deep CNN—MobileNet model | 950 images (Personal + Medetec) | Precision 94.69% | N/A |
Biswas et al., [58] 2018. | SLIC, RGB histogram | SVM—two stages Postprocessing: morphological operation | 110 images | Accuracy 71.98% | N/A |
Manohar Dhane et al., [8] 2017. | Color normalization, noise removal—1st ordered statistic filter, Db color channel | Fuzzy spectral clustering, K-means algorithm | 70 images | Accuracy 91.5% | 180/-/- |
Goyal et al., [42] 2017. | N/A | CNN—FCN-16 model | 705 images | DSC 89.9% | N/A |
Yang et al., [79] 2017. | HSV color space | Multi-task DCNN model | 2150 images | Jaccard Index 72.4% | N/A |
Babu et al., [80] 2017. | N/A | Watershed—flooding and pruning algorithm | 3 images | Accuracy 99.03% | N/A |
Pasero and Castagneri [81] 2017. | Adjust brightness intensity, median filter, HSV color space | Classification based on HSV and RGB color map calculated with Euclidean distance | 35 images | Precision 90.0% | N/A |
L. Wang et al., [46] 2017. | Cropping to 560 × 320, CIELab color space, SLIC | Two-stage SVM | 100 images | Specificity 94.6% | 17.5/15.4/20.5 |
David et al., [57] 2017. | Grayscale | Synthetic frequencies, Otsu’s threshold method | 51 images | Average correlation 0.89 | 9.04/-/- |
Gupta [49] 2017. | HSV color space, median filter, dilation | Otsu’s threshold method, Suzuki85 algorithm | 20 images | Accuracy 70% | 50/-/- |
Dalya and Shedge [50] 2017. | Compression with YCbCr color space, HSI color space | Feature-based (K-means), Edge-based (SVM), Threshold-based, Region-based | 1 image | N/A | N/A |
Kavitha et al., [63] 2017. | YCbCr color space, color correction, noise removal, color homogenization | Factorization based segmentation | N/A | N/A | N/A |
Lu et al., [16] 2016. | Color correction, FLSM (Fast Level Set Model) intensity correction | CNN | 300 images (Medetec) | Accuracy 82% | N/A |
Demyanov et al., [82] 2016. | N/A | Deep CNN | 211 images (ISIC database) | Accuracy 88% | N/A |
Lee et al., [54] 2016. | CIELab color space | Euclidean distance, Otsu’s threshold method, Gradient vector flow | 3 images | N/A | N/A |
Dhane et al., [48] 2016. | Color correction, HSI color space, noise removal | Spectral clustering, k-means | 105 images (Personal + Medetec) | Accuracy 86.73% | 149/-/- |
Veredas, et al., [56] 2015. | CIELUV color space, k-means | Color histograms models, Bayes rule | 435 images | Accuracy 87.77% | 0.3214/-/- |
Khan et al., [83] 2015. | Median filter, image sharpening—high pass filters | Otsu’s threshold method, Water segmentation | N/A | N/A | N/A |
Zhang et al., [84] 2015. | Morphological opening and closing, grayscale, noise removal | Canny edge detection, image binarization | 200 images | N/A | N/A |
C. Wang et al., [85] 2015. | Cropping | CNN—ConvNet model, SVM | 650 images (NYU Wound Database) | Accuracy 95% | 5/-/- |
Kumar and Reddy [13] 2014. | N/A | Wound Image Analysis Classifier (WIAC) algorithm | 50 images | N/A | N/A |
Yadav et al., [52] 2013. | Color correction, color homogenization, median filter, YDbDr color space | K-means, Fuzzy C-means | 77 images (Medetec) | Accuracy 75.23% | N/A |
Paper | Preprocessing/Segmentation | Classification | Image Database | Performance Metrics | Time (s) Avg/Min/Max |
---|---|---|---|---|---|
Chakraborty [11] 2019. | Median filter, YDbDr color space, color homogenization, color correction/Fuzzy C-means | Linear discriminant analysis, Decision Tree, Naive Bayesian, Random forest | 153 images (Personal + Medetec) | Accuracy DT 84.29%, LDA 85.67%, NB 78.66%, RF 93.75% | 120/-/- |
Shenoy et al., [44] ** 2019. | Cropping 224 × 224, CLAHE/CNN—VGG-16 modified model | CNN—modified VGG-16 | 1335 images | Accuracy 82% | N/A |
Rajathi et al., [12] 2019. | Flashlight removal, Grayscale/Active contour technique, gradient descent algorithm | CNN | 1250 images | Accuracy 99.55% | N/A |
Zhao et al., [65] ** 2019. | Image cropping with the app, sharpening images, resize, image augmentation/Bi-CNN—VGG-16 model | Bi-CNN—VGG-16 model | 1639 images | Accuracy Wound depth 84.57%, Granulation 84.57% | N/A |
Pholberdee et al., [94] ** 2018. | Image cropping 31 × 31/CNN | CNN, Post- processing: morphological closing, dilation | 180 images (Medetec) | Precision 56.92% | 10/-/- |
Patel et al. [95] 2018. | HIS color space, noise removal/Gabor filter | K-means | 1 image | N/A | N/A |
Vıtor et al., [47] 2018. | Noise removal, HSV color space/Region growing Watershed algorithm | CNN—U-Net model | 30 images | Accuracy Segmentation 98.92%, Classification 96.1% | N/A |
Nizam et al., [86] * 2018. | N/A | Fuzzy C-means, Unsure, sure, granulation and epithelial region analysis | 600 images | Accuracy Granulation 87.6%, Slough 82.4%, Eschar 89.3%, Epithelial 82.0% | N/A |
Maity et al., [9] * 2018. | N/A | DNN | 250 images + Medetec | Accuracy 99.99% | N/A |
Fauzi et al., [37] ** 2018. | HSV color space modified/Region growing, optimal thresholding | Region growing, optimal thresholding | 80 images | Accuracy overall for both methods 75.1% | 1/-/- |
Elmogy et al., [43] 2018. | HSV color space, Grayscale, Gaussian smoothing/3D CNN | 3D CNN | 193 images (Medetec) | DSC 92% | N/A |
Elmogy et al., [91] 2018. | RGB, HSV and YCbCr color spaces/3D CNN | 3D CNN | 36 images (Igurco), 64 images (Medetec) | DSC Segmentation 96%, Classification 93% | N/A |
García-Zapirain et al., [33] 2018. | Gauss noise removal, HSI color space/3D CNN | 3D CNN | 193 images (Medetec) | DSC Segmentation 95%, Classification 92% | N/A |
Nejati et al., [45] ** 2018. | Image cropping 20 × 20/DNN—AlexNet model, Principal component analysis (PCA), SVM | DNN—AlexNet model, PCA, SVM | 350 images | 86.4% | N/A |
Zahia et al., [41] ** 2018. | Grayscale, Otsu’s threshold method, dilation, cropping 5 × 5/CNN | CNN | 22 images | 92% | 61/46/83 |
García-Zapirain et al., [92] 2017. | Grayscale/Otsu’s threshold method, toroidal geometry | Linear combination of discrete Gaussians (LCDG) | 48 images (Igurco database) | Accuracy 90.4% | 290.4/-/- |
Chakraborty [7] 2017. | Noise removal, color homogenization, grayscale/Particle swarm optimization (PSO) | Linear discriminant analysis | 29 images (Medline, Medetec) | Accuracy Segmentation 98.93%, Classification 98% | 10/-/- |
Chakraborty et al., [90] 2016. | Color correction, noise removal, color homogenization, Db channel/Fuzzy C-means | Linear discriminant analysis | 60 images | Accuracy Segmentation 98.98%, Classification 91.45% | N/A |
L. Wang et al., [55] 2016. | RYB color model/Mean shift | K-means algorithm | 32 images | MCC value 0.68 | 6/-/- |
L. Wang et al., [34] 2015. | RGB compression 4 times, noise removal/Mean shift, largest connected component | K-means | 64 images | MMC 0.736 | 15/-/- |
Chakraborty et al., [88] 2015. | Color correction, median filter, color homogenization, YDbDr—Db and Dr channel/K-means, Fuzzy C-means | Bayesian classifier | 50 images | Accuracy Fuzzy C-means 96.25%, K-means 93.45%, Bayesian classifier 87.11% | 120/-/- |
Veredas et al. [40] 2015. | Median filter, color space transformations/K-means | SVM, NN, RF | 113 images | Accuracy SVM 88.08%, NN 81.87.%, RF 87.37% | 69.5/-/ |
Mukherjee et al., [3] 2014. | Noise removal, HIS—H channel/Fuzzy divergence thresholding | SVM, Bayesian classifier | 74 images (Medetec) | Accuracy Bayes classifier 81.15%, SVM 86.13% | N/A |
Navas et al., [60] 2013. | Median filter/K-means | MLP neural network | 113 images | Accuracy 86% | N/A |
Paper | Preprocessing/Segmentation/Classification | 3D Reconstruction/Healing Prediction/Measurement | Image Database | Performance Metrics | Avg. Time (s) |
---|---|---|---|---|---|
Barbosa et al., [103] 2020. | -/Watershed algorithm/- | Structure from motion, nearest neighbor field (NNF)/-/Marker with math. model | 90 images | 3D measurements average error images 3.8% | 205 |
Shirley et al., [104] 2019. | CIELab color space/Color thresholding and clustering/- | Structure from motion/-/Marker with math. model | 3 image sequences | Error length 4.25%, area 15.33%, volume 17.46% | N/A |
Shi et al., [105] 2019. | Modified HSV color space/Manually contoured/Histogram thresholding | -/Wound healing index (trend)/Manually measured | 119 images of one wound during 90 days | N/A | N/A |
Khalil et al., [106] 2019. | CLAHE/-/Gradient boosted trees (GBT) classifier | -/Healing assessment index based on differences between tissue type in consecutive images/- | 377 images (36 personal + 341 Medetec) + 22 healing image sets | Accuracy tissue classification 96%, healing accuracy 95% compared with a clinical diagnosis | 25 |
Chang et al., [107] 2018. | -/GrabCut algorithm/Mean shift and random forest | Segmented wound and depth view with convex hull for surface/Analysis of thermal, spectral, and chemical vapor for healing prediction/From 3D model | 133 scanning sessions from 23 enrolled subjects | Measurement correlation score for width and length 0.96, 0.46 for depth, healing error 28.57% RF chemical analysis, 23.75% thermal analysis | N/A |
Fauzi et al., [37] 2018. | HSV color space modified/Region grow., optimal thresh./Region grow., optimal thresh. | -/-/Math model based on white labeled card | 80 images | Accuracy area 75%, length 87%, width 85% | 1/-/- |
Filko et al., [71] 2018. | KNN, HSV color space, surfels (superpixels)/Modified region growing, edge spline interpolation/- | ICP, TSDF, Marching cubes algorithm/-/From reconstructed 3D model | Images of Saymour II wound care model | Error perimeter 2.0–9.35% Error area 0.149–20.75% Error volume 8.0–39.69% | 0.477 |
Dan and Carol [108] 2017. | YCbCr color space/Otsu’s threshold method, SVM/- | -/-/Comparing ruler with wound | 239 images (dimensions 32 images) | Correlation with digital planimetry length 0.85, width 0.81, area 0.82 | N/A |
Haider et al., [53] 2016. | CIELab color space, erosion/-/K-means | -/Based on the yellow color pixels measure from Hue (HSV)/- | 10 images | N/A | N/A |
Dadkhah et al., [2] 2016. | Noise removal/Graph cut algorithm, region growing algorithm/- | -/-/Quantification of wound size (length + width) | 9 healing/non-healing lower extremity ulcers | N/A | N/A |
L. Wang et al., [55] 2016. | RYB color model/Mean-shift/K-means | -/Wound healing score math model based on RYB model/Pixel multiply with constant | 28 images | Comparing healing consistency KAC value 0.42 to 0.81 | 6 |
Gaur et al., [102] 2015. | Noise removal/Sobel operator, dilation, erosion/- | Registration and fusion/From depth/Fixed scale with math. model | Synthetic wound models and 3 images | Accuracy Synthetic wound model 70% depth, 80% area, 85% volume | N/A |
C. Wang et al., [85] 2015. | Cropping/CNN ConvNet mode, SVM/- | -/Gaussian process regression (GPR)/Ruler with math. model | 650 images, 192 wound sequences (NYU Wound Database) | Healing Avg. MAEarea 3.95% | 5 |
Zhang et al., [84] 2015. | Morphological filtering, grayscale/Canny edge detection, image binarization/- | -/-/1 cm2 square reference with math. model | 200 images | Average relative error +/− 1.112% | N/A |
Banchev [109] 2014. | Filtering of blobs/Gradient vector flow (GVF)/- | -/-/Reference shape with math. model | Artificially created using a photo editor | Average Error 11.35 pixel/mm | 1 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Marijanović, D.; Filko, D. A Systematic Overview of Recent Methods for Non-Contact Chronic Wound Analysis. Appl. Sci. 2020, 10, 7613. https://doi.org/10.3390/app10217613
Marijanović D, Filko D. A Systematic Overview of Recent Methods for Non-Contact Chronic Wound Analysis. Applied Sciences. 2020; 10(21):7613. https://doi.org/10.3390/app10217613
Chicago/Turabian StyleMarijanović, Domagoj, and Damir Filko. 2020. "A Systematic Overview of Recent Methods for Non-Contact Chronic Wound Analysis" Applied Sciences 10, no. 21: 7613. https://doi.org/10.3390/app10217613
APA StyleMarijanović, D., & Filko, D. (2020). A Systematic Overview of Recent Methods for Non-Contact Chronic Wound Analysis. Applied Sciences, 10(21), 7613. https://doi.org/10.3390/app10217613