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Mutation Rate Model Used in the DNA VIEW Program

Department of Production Computerisation and Robotisation, Lublin University of Technology, 20-618 Lublin, Poland
Appl. Sci. 2020, 10(10), 3585; https://doi.org/10.3390/app10103585
Received: 14 April 2020 / Revised: 19 May 2020 / Accepted: 20 May 2020 / Published: 22 May 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
The first problem considered in this paper is the problem of correctness of a mutation model used in the DNA VIEW program. To this end, we theoretically predict population allele frequency changes in time according to this and similar models (we determine the limit frequencies of alleles—they are uniformly distributed). Furthermore, we evaluate the speed of the above changes using computer simulation applied to our DNA database. Comparing uniformly distributed allele frequencies with these existing in the population (for example, using entropy), we conclude that this mutation model is not correct. The evolution does not follow this direction (direction of uniformly distributed frequencies). The second problem relates to the determination of the extent to which an incorrect mutation model can disturb DNA VIEW program results. We show that in typical computations (simple paternity testing without maternal mutation) this influence is negligible, but in the case of maternal mutation, this should be taken into account. Furthermore, we show that this model is inconsistent from a theoretical viewpoint. Equivalent methods result in different error levels. View Full-Text
Keywords: fingerprinting DNA; paternity testing; DNA VIEW program; mutation model; the rate of mutation; population; Allele frequencies fingerprinting DNA; paternity testing; DNA VIEW program; mutation model; the rate of mutation; population; Allele frequencies
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Krajka, T. Mutation Rate Model Used in the DNA VIEW Program. Appl. Sci. 2020, 10, 3585.

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