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Behav. Sci. 2018, 8(10), 89; https://doi.org/10.3390/bs8100089

Faecal Microbial Markers and Psychobiological Disorders in Subjects with Morbid Obesity. A Cross-Sectional Study

1
Department of Research, Innlandet Hospital Trust, PB 104, N-2381 Brumunddal, Norway
2
Unit for Applied Clinical Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, N-7491 Trondheim, Norway
3
Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, N-0440 Oslo, Norway
*
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 12 September 2018 / Accepted: 22 September 2018 / Published: 27 September 2018
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Abstract

Morbidly obese subjects have a high prevalence of comorbidity and gut microbial dysbiosis, and are thus suitable for the study of gut-brain interactions. The aim was to study the associations between the faecal microbiota’s composition and function and psychobiological comorbidity in subjects with BMI > 40 kg/m2 or >35 kg/m2 with obesity-related complications. The faecal microbiota was assessed with GA-Map dysbiosis test ™ (Genetic Analysis, Oslo Norway) and reported as dysbiosis (yes/no) and degree of dysbiosis, and the relative abundance of 39 bacteria. The microbiota’s function was assessed by measuring the absolute and relative amount of faecal short chain fatty acids. Associations were made with well-being, mental distress, fatigue, food intolerance, musculoskeletal pain, irritable bowel syndrome, and degree of abdominal complaints. One hundred and two subjects were included. The results confirmed the high prevalence of comorbidity and dysbiosis (62/102; 61%) and showed a high prevalence of significant associations (41/427; 10%) between the microbiota’s composition and function and the psychobiological disorders. The abundant, but in part divergent, associations supported the close gut-brain interaction but revealed no clear-cut and straightforward communication pathways. On the contrary, the study illustrates the complexity of gut-brain interactions. View Full-Text
Keywords: gut-brain axis; faecal microbiota; faecal short chain fatty acids; morbid obesity; psychobiological disorders; well-being; mental distress; irritable bowel syndrome gut-brain axis; faecal microbiota; faecal short chain fatty acids; morbid obesity; psychobiological disorders; well-being; mental distress; irritable bowel syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Farup, P.G.; Valeur, J. Faecal Microbial Markers and Psychobiological Disorders in Subjects with Morbid Obesity. A Cross-Sectional Study. Behav. Sci. 2018, 8, 89.

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