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Impaired Recovery from Influenza A/X-31(H3N2) Infection in Mice with 8-Lipoxygenase Deficiency

1
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
2
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
*
Author to whom correspondence should be addressed.
Med. Sci. 2019, 7(4), 60; https://doi.org/10.3390/medsci7040060
Received: 23 December 2018 / Revised: 3 April 2019 / Accepted: 9 April 2019 / Published: 12 April 2019
(This article belongs to the Section Immunology and Infectious Diseases)
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Abstract

Lipoxygenase-derived lipid mediators can modulate inflammation and are stimulated in response to influenza infections. We report an effect of 8-lipoxygenase (ALOX8) on the recovery of mice after infection with Influenza virus X31. We compared the responses of 3- and 6-month-old mice with a deletion of ALOX8 (ALOX8−/−) to influenza infections with those of age-matched littermate wild-type mice (ALOX8+/+). The duration of illness was similar in 3-month-old ALOX8−/− and ALOX8+/+ mice. However, the 6-month-old ALOX8−/− mice showed a prolonged state of illness compared with ALOX8+/+ mice, as evidenced by reduced body temperatures, reduced locomotor activities, and delayed weight recovery. Although residual viral RNA in the lungs at day 10 post-inoculation was significantly influenced by the age of the ALOX8−/− mice, there were no significant differences between ALOX8−/− and ALOX8+/+ mice within the same age groups. The levels of cytokines interleukin 6 (IL-6) and keratinocyte chemoattractant (KC) differed significantly between 6-month-old ALOX8−/− and ALOX8+/+ mice 10 days after viral inoculation. Our data suggest that ALOX8 deficiency in mice leads to impaired recovery from influenza infection in an age-dependent manner. View Full-Text
Keywords: influenza A; X-31; lipoxygenase; ALOX8; inflammation; resolution; knockout mice influenza A; X-31; lipoxygenase; ALOX8; inflammation; resolution; knockout mice
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Alfardan, R.; Guo, C.; Toth, L.A.; Nie, D. Impaired Recovery from Influenza A/X-31(H3N2) Infection in Mice with 8-Lipoxygenase Deficiency. Med. Sci. 2019, 7, 60.

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