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Human Dendritic Cells: Ontogeny and Their Subsets in Health and Disease

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Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
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Departamento de Microbiología, Centro de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud (CICSA), Universidad Anáhuac México Campus Norte, Estado de México 52786, Mexico
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Medical IMPACT, Infectious Diseases Department, Mexico City 53900, Mexico
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Coordinación del Centro de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud (CICSA), Universidad Anáhuac México Campus Norte, Estado de México 52786, Mexico
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Unidad de Investigación UNAM-INC, División Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México-Instituto Nacional de Cardiología “Ignacio Chávez”, Mexico City 14080, Mexico
*
Author to whom correspondence should be addressed.
Med. Sci. 2018, 6(4), 88; https://doi.org/10.3390/medsci6040088
Received: 4 July 2018 / Revised: 13 September 2018 / Accepted: 4 October 2018 / Published: 8 October 2018
(This article belongs to the Special Issue Innate Immunity Regulating Antigen Presentation)
Dendritic cells (DCs) are a type of cells derived from bone marrow that represent 1% or less of the total hematopoietic cells of any lymphoid organ or of the total cell count of the blood or epithelia. Dendritic cells comprise a heterogeneous population of cells localized in different tissues where they act as sentinels continuously capturing antigens to present them to T cells. Dendritic cells are uniquely capable of attracting and activating naïve CD4+ and CD8+ T cells to initiate and modulate primary immune responses. They have the ability to coordinate tolerance or immunity depending on their activation status, which is why they are also considered as the orchestrating cells of the immune response. The purpose of this review is to provide a general overview of the current knowledge on ontogeny and subsets of human dendritic cells as well as their function and different biological roles. View Full-Text
Keywords: conventional DCs (cDCs); human dendritic cells; monocyte-derived DCs (moDCs); myeloid DCs (mDCs); ontogeny; plasmacytoid DCs (pDCs); subsets conventional DCs (cDCs); human dendritic cells; monocyte-derived DCs (moDCs); myeloid DCs (mDCs); ontogeny; plasmacytoid DCs (pDCs); subsets
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Solano-Gálvez, S.G.; Tovar-Torres, S.M.; Tron-Gómez, M.S.; Weiser-Smeke, A.E.; Álvarez-Hernández, D.A.; Franyuti-Kelly, G.A.; Tapia-Moreno, M.; Ibarra, A.; Gutiérrez-Kobeh, L.; Vázquez-López, R. Human Dendritic Cells: Ontogeny and Their Subsets in Health and Disease. Med. Sci. 2018, 6, 88.

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