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Med. Sci. 2018, 6(2), 27; https://doi.org/10.3390/medsci6020027

Live Bacterial Vectors—A Promising DNA Vaccine Delivery System

Department of Pharmacy, Medical Faculty, Universitas Brawijaya, East Java 65145, Malang, Indonesia
Received: 24 January 2018 / Revised: 19 March 2018 / Accepted: 19 March 2018 / Published: 23 March 2018
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Abstract

Vaccination is one of the most successful immunology applications that has considerably improved human health. The DNA vaccine is a new vaccine being developed since the early 1990s. Although the DNA vaccine is promising, no human DNA vaccine has been approved to date. The main problem facing DNA vaccine efficacy is the lack of a DNA vaccine delivery system. Several studies explored this limitation. One of the best DNA vaccine delivery systems uses a live bacterial vector as the carrier. The live bacterial vector induces a robust immune response due to its natural characteristics that are recognized by the immune system. Moreover, the route of administration used by the live bacterial vector is through the mucosal route that beneficially induces both mucosal and systemic immune responses. The mucosal route is not invasive, making the vaccine easy to administer, increasing the patient’s acceptance. Lactic acid bacterium is one of the most promising bacteria used as a live bacterial vector. However, some other attenuated pathogenic bacteria, such as Salmonella spp. and Shigella spp., have been used as DNA vaccine carriers. Numerous studies showed that live bacterial vectors are a promising candidate to deliver DNA vaccines. View Full-Text
Keywords: lactic acid bacteria; antigen expression; oral delivery; carrier lactic acid bacteria; antigen expression; oral delivery; carrier
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Yurina, V. Live Bacterial Vectors—A Promising DNA Vaccine Delivery System. Med. Sci. 2018, 6, 27.

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