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Med. Sci. 2015, 3(3), 64-77;

Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 117597, Singapore
Laboratory of Microbial Immunity, Singapore Immunology Network, Agency for Science, Technology and Research (AA*STAR), 8A Biomedical Grove, #04-06 Immunos, Singapore 138648, Singapore
Author to whom correspondence should be addressed.
Academic Editor: Li-Yun Chang
Received: 2 June 2015 / Revised: 20 July 2015 / Accepted: 20 July 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Innate Immunity and Infectious Diseases)
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Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes febrile chikungunya fever (CHIKF) in humans. This disease is debilitating and characterized by acute fever onset and chronic incapacitating polyarthralgia. CHIKF pathogenesis remains poorly defined with no approved vaccines and therapies. Recent outbreaks in the Caribbean islands have elevated concerns over the possibility of a global pandemic. Tremendous efforts have been made to develop relevant mouse models to enable the study of infection and immunity against this viral disease. Among them, the more common C57BL/6 mouse model demonstrated the ability to recapitulate the symptoms shown in infected humans, including self-limiting arthritis, myositis, and tenosynovitis. This has facilitated the unraveling of some key factors involved in disease pathogenesis of CHIKF. However, the stark differences in immune response between humans and mouse models necessitate the development of an animal model with an immune system that is more genetically similar to the human system for a better representation. In this paper, we aim to uncover the limitations of the C57BL/6 model and discuss alternative mouse models for CHIKV research. View Full-Text
Keywords: alphavirus; chikungunya; mouse models; pathogenesis; immunity alphavirus; chikungunya; mouse models; pathogenesis; immunity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chan, Y.-H.; Lum, F.-M.; Ng, L.F.P. Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis. Med. Sci. 2015, 3, 64-77.

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