Associations between Oxytocin Receptor Gene Polymorphisms, Empathy towards Animals and Implicit Associations towards Animals
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Ethics
2.2. Measures
2.2.1. Empathy Measures
2.2.2. Implicit Associations
2.3. Saliva Sampling and DNA Extraction
2.4. SNP Sequencing
2.5. Statistics
2.6. Participants
3. Results
3.1. Empathy Measures
3.2. Implicit Associations to Animals (IAT)
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- Hemsworth, P.H. Human–animal interactions in livestock production. Appl. Anim. Behav. Sci. 2003, 81, 185–198. [Google Scholar] [CrossRef]
- Fidler, M.; Coleman, P.; Roberts, A. Empathic response to animal suffering: Societal versus family influence. Anthrozoös 2000, 13, 48–51. [Google Scholar] [CrossRef]
- Gurusamy, V.; Tribe, A.; Toukhsati, S.; Phillips, C.J.C. Public attitudes in india and australia toward elephants in zoos. Anthrozoös 2015, 28, 87–100. [Google Scholar] [CrossRef]
- Furnham, A.; McManus, C.; Scott, D. Personality, empathy and attitudes to animal welfare. Anthrozoös 2003, 16, 135–146. [Google Scholar] [CrossRef]
- Hills, A.M. The motivational bases of attitudes toward animals. Soc. Anim. 1993, 1, 111–128. [Google Scholar] [CrossRef]
- Rae Westbury, H.; Neumann, D.L. Empathy-related responses to moving film stimuli depicting human and non-human animal targets in negative circumstances. Biol. Psychol. 2008, 78, 66–74. [Google Scholar] [CrossRef] [PubMed]
- Paul, E.S.; Serpell, J.A. Childhood pet keeping and humane attitudes in young adulthood. Anim. Welf. 1993, 2, 321–337. [Google Scholar]
- Kellert, S.R.; Berry, J.K.; Yale, U.; Fish, U.S.; Wildlife, S. Knowledge, Affection and Basic Attitudes toward Animals in American Society; U.S. Fish and Wildlife Service: Washington, DC, USA, 1982; 162p.
- Plous, S. Psychological mechanisms in the human use of animals. J. Soc. Issues 1993, 49, 11–52. [Google Scholar] [CrossRef]
- Serpell, J.A. Factors influencing human attitudes to animals and their welfare. Anim. Welf. 2004, 13, 145–151. [Google Scholar]
- Eisenberg, N. Empathy and sympathy: A brief review of the concepts and empirical literature. Anthrozoös 1988, 2, 15–17. [Google Scholar] [CrossRef]
- Davis, M.H. Measuring individual differences in empathy: Evidence for a multidimensional approach. J. Personal. Soc. Psychol. 1983, 44, 113–126. [Google Scholar] [CrossRef]
- Henrik, W. Social cognitive neuroscience of empathy: Concepts, circuits, and genes. Emot. Rev. 2012, 4, 9–17. [Google Scholar]
- Batson, C.D.; Shaw, L.L. Evidence for altruism: Toward a pluralism of prosocial motives. Psychol. Inq. 1991, 2, 107–122. [Google Scholar] [CrossRef]
- Batson, C.D.; Polycarpou, M.P.; Harmon-Jones, E.; Imhoff, H.J.; Mitchener, E.C.; Bednar, L.L.; Klein, T.R.; Highberger, L. Empathy and attitudes: Can feeling for a member of a stigmatized group improve feelings toward the group? J. Personal. Soc. Psychol. 1997, 72, 105–118. [Google Scholar] [CrossRef] [Green Version]
- Taylor, N.; Signal, T.D. Empathy and attitudes to animals. Anthrozoös 2005, 18, 18–27. [Google Scholar] [CrossRef] [Green Version]
- Paul, E.S. Empathy with animals and with humans: Are they linked? Anthrozoös 2000, 13, 194–202. [Google Scholar] [CrossRef]
- Kielland, C.; Skjerve, E.; Østerås, O.; Zanella, A.J. Dairy farmer attitudes and empathy toward animals are associated with animal welfare indicators. J. Dairy Sci. 2010, 93, 2998–3006. [Google Scholar] [CrossRef] [PubMed]
- Hanna, D.; Sneddon, I.A.; Beattie, V.E. The relationship between the stockperson’s personality and attitudes and the productivity of dairy cows. Animal 2009, 3, 737–743. [Google Scholar] [CrossRef] [PubMed]
- Norring, M.; Wikman, I.; Hokkanen, A.-H.; Kujala, M.V.; Hänninen, L. Empathic veterinarians score cattle pain higher. Vet. J. 2014, 200, 186–190. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ellingsen, K.; Zanella, A.J.; Bjerkås, E.; Indrebø, A. The relationship between empathy, perception of pain and attitudes toward pets among norwegian dog owners. Anthrozoös 2010, 23, 231–243. [Google Scholar] [CrossRef]
- Angantyr, M.; Eklund, J.; Hansen, E.M. A comparison of empathy for humans and empathy for animals. Anthrozoös 2011, 24, 369–377. [Google Scholar] [CrossRef]
- O’Connell, L.A.; Hofmann, H.A. Genes, hormones, and circuits: An integrative approach to study the evolution of social behavior. Front. Neuroendocrinol. 2011, 32, 320–335. [Google Scholar] [CrossRef] [PubMed]
- Baumeister, R.F.; Leary, M.R. The need to belong: Desire for interpersonal attachments as a fundamental human motivation. Psychol. Bull. 1995, 117, 497–529. [Google Scholar] [CrossRef] [PubMed]
- Heinrichs, M.; Domes, G. Neuropeptides and social behaviour: Effects of oxytocin and vasopressin in humans. In Progress in Brain Research; Neumann, I.D., Landgraf, R., Eds.; Elsevier: New York, NY, USA, 2008; Volume 170, pp. 337–350. [Google Scholar]
- SNPedia. Available online: https://www.snpedia.com/index.php/Oxtr._(10.02.2016).Hom_1_* (accessed on 14 August 2018).
- Ebstein, R.P.; Knafo, A.; Mankuta, D.; Chew, S.H.; Lai, P.S. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm. Behav. 2012, 61, 359–379. [Google Scholar] [CrossRef] [PubMed]
- Tost, H.; Kolachana, B.; Hakimi, S.; Lemaitre, H.; Lemaitre, H.; Verchinski, B.A.; Mattay, V.S.; Weinberger, D.R.; Meyer-Lindenberg, A. A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc. Natl. Acad. Sci. USA 2010, 107, 13936–13941. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Rodrigues, S.M.; Saslow, L.R.; Garcia, N.; John, O.P.; Keltner, D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc. Natl. Acad. Sci. USA 2009, 106, 21437–21441. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kim, H.S.; Sherman, D.K.; Sasaki, J.Y.; Xu, J.; Chu, T.Q.; Ryu, C.; Suh, E.M.; Graham, K.; Taylor, S.E. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc. Natl. Acad. Sci. USA 2010, 107, 15717–15721. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- LeClair, J.; Sasaki, J.Y.; Ishii, K.; Shinada, M.; Kim, H.S. Gene–culture interaction: Influence of culture and oxytocin receptor gene (OXTR) polymorphism on loneliness. Cult. Brain 2016, 4, 21–37. [Google Scholar] [CrossRef]
- Apter-Levy, Y.; Feldman, M.; Vakart, A.; Ebstein, R.P.; Feldman, R. Impact of maternal depression across the first 6 years of life on the child’s mental health, social engagement, and empathy: The moderating role of oxytocin. Am. J. Psychiatry 2013, 170, 1161–1168. [Google Scholar] [CrossRef] [PubMed]
- Thompson, R.J.; Parker, J.F.; Hallmayer, J.F.; Waugh, C.E.; Gotlib, I.H. Oxytocin receptor gene polymorphism (RS2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology 2011, 1, 144–147. [Google Scholar] [CrossRef] [PubMed]
- Lucht, M.J.; Barnow, S.; Sonnenfeld, C.; Rosenberger, A.; Grabe, H.J.; Schroeder, W.; Völzke, H.; Freyberger, H.J.; Herrmann, F.H.; Kroemer, H.; et al. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2009, 33, 860–866. [Google Scholar] [CrossRef] [PubMed]
- Montag, C.; Brockmann, E.-M.; Lehmann, A.; Müller, D.J.; Rujescu, D.; Gallinat, J. Association between oxytocin receptor gene polymorphisms and self-rated ‘empathic concern’ in schizophrenia. PLoS ONE 2012, 7, e51882. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wu, N.; Li Z Fau-Su, Y.; Su, Y. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J. Affect. Disord. 2012, 138, 468–472. [Google Scholar] [CrossRef] [PubMed]
- Kosfeld, M.; Heinrichs, M.; Zak, P.J.; Fischbacher, U.; Fehr, E. Oxytocin increases trust in humans. Nature 2005, 435, 673. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Domes, G.; Heinrichs, M.; Michel, A.; Berger, C.; Herpertz, S.C. Oxytocin improves “mind-reading” in humans. Biol. Psychiatry 2007, 61, 731–733. [Google Scholar] [CrossRef] [PubMed]
- Guastella, A.J.; Mitchell, P.B.; Dadds, M.R. Oxytocin increases gaze to the eye region of human faces. Biol. Psychiatry 2008, 63, 3–5. [Google Scholar] [CrossRef] [PubMed]
- Leng, G.; Ludwig, M. Intranasal oxytocin: Myths and delusions. Biol. Psychiatry 2016, 79, 243–250. [Google Scholar] [CrossRef] [PubMed]
- Bartz, J.A.; Zaki, J.; Bolger, N.; Ochsner, K.N. Social effects of oxytocin in humans: Context and person matter. Trends Cogn. Sci. 2011, 15, 301–309. [Google Scholar] [CrossRef] [PubMed]
- Declerck, C.H.; Boone, C.; Kiyonari, T. Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information. Horm. Behav. 2010, 57, 368–374. [Google Scholar] [CrossRef] [PubMed]
- Shamay-Tsoory, S.G.; Fischer, M.; Dvash, J.; Harari, H.; Perach-Bloom, N.; Levkovitz, Y. Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biol. Psychiatry 2009, 66, 864–870. [Google Scholar] [CrossRef] [PubMed]
- Persson, M.E.; Trottier, A.J.; Bélteky, J.; Roth, L.S.V.; Jensen, P. Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs. Horm. Behav. 2017, 95, 85–93. [Google Scholar] [CrossRef] [PubMed]
- Kis, A.; Bence, M.; Lakatos, G.; Pergel, E.; Turcsán, B.; Pluijmakers, J.; Vas, J.; Elek, Z.; Brúder, I.; Földi, L.; et al. Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris). PLoS ONE 2014, 9, e83993. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kis, A.; Ciobica, A.; Topál, J. The effect of oxytocin on human-directed social behaviour in dogs (Canis familiaris). Horm. Behav. 2017, 94, 40–52. [Google Scholar] [CrossRef] [PubMed]
- De Houwer, J. What are implicit measures and why are we using them. In The Handbook of Implicit Cognition and Addiction; Jon Wiers, R.W.H., Stacy, A.W., Eds.; Sage Publications: Thousand Oaks, CA, USA, 2006; pp. 11–28. [Google Scholar]
- Slovic, P. The construction of preference. Am. Psychol. 1995, 50, 364–371. [Google Scholar] [CrossRef]
- De Vignemont, F.; Singer, T. The empathic brain: How, when and why? Trends Cogn. Sci. 2006, 10, 435–441. [Google Scholar] [CrossRef] [PubMed]
- Karpinski, A.; Steinman, R.B. The single category implicit association test as a measure of implicit social cognition. J. Personal. Soc. Psychol. 2006, 91, 16–32. [Google Scholar] [CrossRef] [PubMed]
- Greenwald, A.G.; McGhee, D.E.; Schwartz, J.L.K. Measuring individual differences in implicit cognition: The implicit association test. J. Personal. Soc. Psychol. 1998, 74, 1464–1480. [Google Scholar] [CrossRef]
- Sparklebox. Available online: www.sparklebox.co.uk (accessed on 14 August 2018).
- Uzefovsky, F.; Shalev, I.; Israel, S.; Edelman, S.; Raz, Y.; Mankuta, D.; Knafo-Noam, A.; Ebstein, R.P. Oxytocin receptor and vasopressin receptor 1A genes are respectively associated with emotional and cognitive empathy. Horm. Behav. 2015, 67, 60–65. [Google Scholar] [CrossRef] [PubMed]
- Meyer, I.; Forkman, B.; Paul, E.S. Factors affecting the human interpretation of dog behavior. Anthrozoös 2014, 27, 127–140. [Google Scholar] [CrossRef]
- Mathews, S.; Herzog, H.A. Personality and attitudes toward the treatment of animals. Soc. Anim. 1997, 5, 169–175. [Google Scholar] [CrossRef]
SNP | Hom 1 | Het | Hom 2 | Total | % of Submitted |
---|---|---|---|---|---|
rs2268491 (C/T) | 129 | 19 | 1 | 149 | 92.5 |
rs13316193 (C/T) | 16 | 49 | 55 | 120 | 74.5 |
rs4686302 (C/T) | 121 | 29 | 1 | 151 | 93.8 |
rs2254298 (G/A) | 104 | 25 | 2 | 131 | 81.4 |
rs53576 (G/A) | 64 | 51 | 14 | 129 | 80.1 |
SNP | Coding | N Male | N Female | Total N |
---|---|---|---|---|
rs2268491 | CT/TT (t present) | 6 | 14 | 20 |
CC (t absent) | 45 | 83 | 128 | |
rs13316193 | CT/CC (c present) | 25 | 40 | 65 |
TT (c absent) | 19 | 35 | 54 | |
rs4686302 | CT/TT (t present) | 10 | 20 | 30 |
CC (t absent) | 43 | 77 | 120 | |
rs2254298 | AA/AG (a present) | 7 | 20 | 27 |
GG (a absent) | 38 | 65 | 103 | |
rs53576 | AA/AG (a present) | 23 | 41 | 64 |
GG (a absent) | 21 | 43 | 64 |
Predictor | β | Wald χ2 (1) | p |
---|---|---|---|
Care profession | −0.356 | 4.97 | 0.026 |
Gender | −0.456 | 8.81 | 0.003 |
rs2268491 | −0.687 | 2.61 | 0.106 |
rs13316193 | 0.094 | 0.74 | 0.391 |
rs4686302 | −0.211 | 2.39 | 0.122 |
rs2254298 | −0.799 | 4.12 | 0.042 |
rs53576 | −0.356 | 0.001 | 0.972 |
Predictor | β | Wald χ2 (1) | p |
---|---|---|---|
Care profession | −0.086 | 2.38 | 0.123 |
Gender | −0.020 | 0.15 | 0.701 |
rs2268491 | −0.126 | 0.73 | 0.392 |
rs13316193 | 0.070 | 3.38 | 0.066 |
rs4686302 | −0.006 | 0.02 | 0.898 |
rs2254298 | 0.033 | 0.06 | 0.807 |
rs53576 | 0.099 | 6.11 | 0.013 |
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Connor, M.; Lawrence, A.B.; Brown, S.M. Associations between Oxytocin Receptor Gene Polymorphisms, Empathy towards Animals and Implicit Associations towards Animals. Animals 2018, 8, 140. https://doi.org/10.3390/ani8080140
Connor M, Lawrence AB, Brown SM. Associations between Oxytocin Receptor Gene Polymorphisms, Empathy towards Animals and Implicit Associations towards Animals. Animals. 2018; 8(8):140. https://doi.org/10.3390/ani8080140
Chicago/Turabian StyleConnor, Melanie, Alistair B. Lawrence, and Sarah M. Brown. 2018. "Associations between Oxytocin Receptor Gene Polymorphisms, Empathy towards Animals and Implicit Associations towards Animals" Animals 8, no. 8: 140. https://doi.org/10.3390/ani8080140
APA StyleConnor, M., Lawrence, A. B., & Brown, S. M. (2018). Associations between Oxytocin Receptor Gene Polymorphisms, Empathy towards Animals and Implicit Associations towards Animals. Animals, 8(8), 140. https://doi.org/10.3390/ani8080140