Clinical and Histopathological Features of Renal Maldevelopment in Boxer Dogs: A Retrospective Case Series (1999–2018) †
Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy
Veterinary diagnostic Lab ACV Triggiano, 70019 Triggiano, Italy
Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Author to whom correspondence should be addressed.
This study was partially presented as oral communication at the 11th ECVIM-CA/ESVIM Congress, Dublin (Ireland) as “Congenital nephrotic syndrome with renal glomerular immaturity in 7 Boxer dogs”. Zatelli, A., Domenech, O., Bussadori, C., Lubas, G., Del Piero, F.
Academic Editors: Mandy Paterson and Paola Scarpa
Received: 19 January 2021
Revised: 27 February 2021
Accepted: 11 March 2021
Published: 13 March 2021
This study describes clinical findings in Boxer dogs with renal maldevelopment and proposes a possible mode of inheritance. Medical records of 9 female Boxer dogs, older than 5 months and with a clinical diagnosis of proteinuric chronic kidney disease prior to one year of age, showed the presence of polyuria and polydipsia, decreased appetite, weight loss, lethargy and weakness in all affected dogs. Common laboratory findings were proteinuria and diluted urine, non-regenerative anemia, azotemia, hyperphosphatemia, hypoalbuminemia and hypercholesterolemia. Histopathology of the kidneys identified the presence of immature glomeruli in all dogs. In 7 out of 9 related dogs, the pedigree analysis showed that a simple autosomal recessive trait may be a possible mode of inheritance. Renal glomerular immaturity should be suspected in Boxer dogs with a history of polyuria, polydipsia, decreased appetite, weight loss, lethargy, weakness and proteinuria. A prompt diagnosis of renal maldevelopment, potentially hereditary, may help to evaluate if relatives of the affected dogs might be at risk, thus assisting clinicians in reaching an early diagnosis. A routine clinical renal screening evaluation in this breed, especially when this disease is suspected, should be strongly recommended.