Outcomes from Experimental Testing of Nonsteroidal Anti-Inflammatory Drug (NSAID) Administration during the Transition Period of Dairy Cows
Abstract
:Simple Summary
Abstract
1. Introduction
2. The Use of NSAIDs during Transition Period of Dairy Cows
2.1. Salicylates
2.2. Flunixin Meglumine
2.3. Meloxicam
2.4. Carprofen
3. Another Drug: Pegbovigrastim
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Drug | Target | Half Time | Milk Withdrawal |
---|---|---|---|
Salicylate | COX-1/2 | 0.5 h | 24 h |
Flunexin meglumine | COX-1 preferential | 1.6 h | 36–48 h |
Meloxicam | COX-2 preferential | 26 h | 120 h (0.5 mg/kg BW, i.m.) or 80 h (1 mg/kg BW, os) |
Carprofen | COX-2 selective | 30.7 h | Not required 1 |
NSAIDs | N° Total Cows | Dose | Timing 1 | N° Treatment Days | References |
---|---|---|---|---|---|
Salicylates | 78 | 1.95 g/L (os) | DIM 1 to 7 | 7 | [42] |
78 | 1.95 g/L (os) | DIM 1 to 7 | 7 | [43] | |
51 | 185 mg/kg (os) | 12 to 36 h 2 | 3 | [31] | |
56 | 125 g/d (os) | 12 to 36 h 2 | 3 | [44] | |
22 | 15 g/d + 7.5 g/d (i.m.) | DIM 1 to 3 + DIM 4 to 5 | 5 | [16] | |
Flunexin meglumin | 26 | 2.2 mg/kg (i.v.) | within 5 h 2 | 3 | [51] |
1265 | 1.1 to 2.2 mg/kg (i.v) | within 24 h 2 | 2 | [38] | |
49 | 1–5 g in 30 mL (i.m.) | immediately after caesarean | 1 | [50] | |
60 | 2.2 mg/kg (i.m) | within 12 h 2 | 1 | [52] | |
128 | 2.2 mg/kg (i.v.) | DIM 5 to 8 2 | 2 bid + 2 sid | [53] | |
119 | 2.2 mg/kg (i.v) | DIM 4 to 5 2 | 1 | [54] | |
Meloxicam | 103 | 0.5 mg/kg (s.c.) | 25.4 h 2 | 1 | [59] |
462 | 0.5 mg/kg (s.c.) | within 1 h 2 | 1 | [60] | |
60 | 0.5 mg/kg (s.c.) | within 6 h 2 | 1 | [32] | |
51 | ~1 mg/kg (os) | 12–36 h 2 | 4 | [31] | |
1.009 | ~1 mg/kg (os) | at calving | 1 | [30] | |
361 | 0.5 mg/kg (s.c.) | at the diagnosis of c.m. | 1 | [62] | |
Carprofen | 639 | 1.4 mg/kg (s.c.) | DIM: 1, 3, 5; DIM 19, 21, 23 | 3 | [33] |
213 | 1.4 mg/kg (s.c.) | DIM 21 (every 3 days) | 3 | [17] | |
39 | 1.4 mg/kg (i.v.) | immediately after calving | 1 | [70] | |
60 | 1.4 mg/kg (s.c.) | within 12 h 2 | 1 | [52] |
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Trimboli, F.; Ragusa, M.; Piras, C.; Lopreiato, V.; Britti, D. Outcomes from Experimental Testing of Nonsteroidal Anti-Inflammatory Drug (NSAID) Administration during the Transition Period of Dairy Cows. Animals 2020, 10, 1832. https://doi.org/10.3390/ani10101832
Trimboli F, Ragusa M, Piras C, Lopreiato V, Britti D. Outcomes from Experimental Testing of Nonsteroidal Anti-Inflammatory Drug (NSAID) Administration during the Transition Period of Dairy Cows. Animals. 2020; 10(10):1832. https://doi.org/10.3390/ani10101832
Chicago/Turabian StyleTrimboli, Francesca, Monica Ragusa, Cristian Piras, Vincenzo Lopreiato, and Domenico Britti. 2020. "Outcomes from Experimental Testing of Nonsteroidal Anti-Inflammatory Drug (NSAID) Administration during the Transition Period of Dairy Cows" Animals 10, no. 10: 1832. https://doi.org/10.3390/ani10101832