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Article

Soybean Oil Modulates the Gut Microbiota Associated with Atherogenic Biomarkers

1
Laboratory of Applied Genomics, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel
2
Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
3
The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel
4
Department of Internal Medicine E, Rambam Health Care Campus, Haifa 3109601, Israel
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(4), 486; https://doi.org/10.3390/microorganisms8040486
Received: 11 February 2020 / Revised: 12 March 2020 / Accepted: 25 March 2020 / Published: 30 March 2020
(This article belongs to the Special Issue Animal Microbiota: Securing Optimal Gene-Diet-Microbiota Interactions)
During the last few decades there has been a staggering rise in human consumption of soybean-oil (SO). The microbiome and specific taxa composing it are dramatically affected by diet; specifically, by high-fat diets. Increasing evidence indicates the association between dysbiosis and health or disease state, including cardiovascular diseases (CVD) and atherosclerosis pathogenesis in human and animal models. To investigate the effects of high SO intake, C57BL/6 mice were orally supplemented with SO-based emulsion (SOE) for one month, followed by analyses of atherosclerosis-related biomarkers and microbiota profiling by 16S rRNA gene sequencing of fecal DNA. SOE-supplementation caused compositional changes to 64 taxa, including enrichment in Bacteroidetes, Mucispirillum, Prevotella and Ruminococcus, and decreased Firmicutes. These changes were previously associated with atherosclerosis in numerous studies. Among the shifted taxa, 40 significantly correlated with at least one atherosclerosis-related biomarker (FDR < 0.05), while 13 taxa positively correlated with the average of all biomarkers. These microbial alterations also caused a microbial-derived metabolic-pathways shift, including enrichment in different amino-acid metabolic-pathways known to be implicated in CVD. In conclusion, our results demonstrate dysbiosis following SOE supplementation associated with atherosclerosis-related biomarkers. These findings point to the microbiome as a possible mediator to CVD, and it may be implemented into non-invasive diagnostic tools or as potential therapeutic strategies. View Full-Text
Keywords: microbiota; dysbiosis; soybean oil; atherosclerosis microbiota; dysbiosis; soybean oil; atherosclerosis
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MDPI and ACS Style

Korach-Rechtman, H.; Rom, O.; Mazouz, L.; Freilich, S.; Jeries, H.; Hayek, T.; Aviram, M.; Kashi, Y. Soybean Oil Modulates the Gut Microbiota Associated with Atherogenic Biomarkers. Microorganisms 2020, 8, 486. https://doi.org/10.3390/microorganisms8040486

AMA Style

Korach-Rechtman H, Rom O, Mazouz L, Freilich S, Jeries H, Hayek T, Aviram M, Kashi Y. Soybean Oil Modulates the Gut Microbiota Associated with Atherogenic Biomarkers. Microorganisms. 2020; 8(4):486. https://doi.org/10.3390/microorganisms8040486

Chicago/Turabian Style

Korach-Rechtman, Hila, Oren Rom, Lirane Mazouz, Shay Freilich, Helana Jeries, Tony Hayek, Michael Aviram, and Yechezkel Kashi. 2020. "Soybean Oil Modulates the Gut Microbiota Associated with Atherogenic Biomarkers" Microorganisms 8, no. 4: 486. https://doi.org/10.3390/microorganisms8040486

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