The Uprise of Human Leishmaniasis in Tuscany, Central Italy: Clinical and Epidemiological Data from a Multicenter Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Statistical Analysis
2.2. Ethical Considerations
3. Results
4. Discussion
5. Study Limitations
6. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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VL (tot. 118) | CL (tot. 40) | VL + CL (tot 158) | p-Value | |
---|---|---|---|---|
Male sex | 88 (74.6%) | 26 (65.0%) | 114 (72.2%) | 0.694 |
Frequent outdoor activities | 26 (22.0%) | 3 (9.7%) | 29 (19.5%) | 0.240 |
Owning dogs | 27 (22.9%) | 6 (19.4%) | 33 (22.2%) | 0.619 |
Median age [IQR] | 63.8 [37–75.6] | 38.3 [8–60.7] | 58.7 [25.3–73] | 0.015 |
HIV infection | 4 (3.4%) | 1/35 (2.8%) | 5/154 (3.3%) | 0.547 |
Immunosuppression | 37 (31.4%) | 4 (10.0%) | 41 (26.0%) | 0.196 |
VL | 3 Months | 6 Months | 12 Months | CL | 3 Months | 6 Months | 12 Months |
---|---|---|---|---|---|---|---|
Cure * | 85 (90.4%) | 66 (94.3%) | 51 (99.9%) | Cure § | 23 (82.1%) | 17 (100%) | 11 (100%) |
Failure # | 2 (2.1%) | 2 (2.9%) | 1 (1.9%) | Failure ç | 5 (17.9%) | 0 | 0 |
Death | 7 (7.5%) | 2 (2.9%) | 0 | Death | 0 | 0 | 0 |
Total | 94 | 70 | 52 | Total | 28 | 17 | 11 |
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Barbiero, A.; Spinicci, M.; Aiello, A.; Maruotto, M.; Antonello, R.M.; Formica, G.; Piccica, M.; Isola, P.; Parisio, E.M.; Nardone, M.; et al. The Uprise of Human Leishmaniasis in Tuscany, Central Italy: Clinical and Epidemiological Data from a Multicenter Study. Microorganisms 2024, 12, 1963. https://doi.org/10.3390/microorganisms12101963
Barbiero A, Spinicci M, Aiello A, Maruotto M, Antonello RM, Formica G, Piccica M, Isola P, Parisio EM, Nardone M, et al. The Uprise of Human Leishmaniasis in Tuscany, Central Italy: Clinical and Epidemiological Data from a Multicenter Study. Microorganisms. 2024; 12(10):1963. https://doi.org/10.3390/microorganisms12101963
Chicago/Turabian StyleBarbiero, Anna, Michele Spinicci, Andrea Aiello, Martina Maruotto, Roberta Maria Antonello, Giuseppe Formica, Matteo Piccica, Patrizia Isola, Eva Maria Parisio, Maria Nardone, and et al. 2024. "The Uprise of Human Leishmaniasis in Tuscany, Central Italy: Clinical and Epidemiological Data from a Multicenter Study" Microorganisms 12, no. 10: 1963. https://doi.org/10.3390/microorganisms12101963
APA StyleBarbiero, A., Spinicci, M., Aiello, A., Maruotto, M., Antonello, R. M., Formica, G., Piccica, M., Isola, P., Parisio, E. M., Nardone, M., Valentini, S., Mangano, V., Brunelli, T., Bianchi, L., Bartalesi, F., Costa, C., Sambo, M., Tumbarello, M., Sani, S., ... Zammarchi, L. (2024). The Uprise of Human Leishmaniasis in Tuscany, Central Italy: Clinical and Epidemiological Data from a Multicenter Study. Microorganisms, 12(10), 1963. https://doi.org/10.3390/microorganisms12101963