Novel Knowledge of Macrolide Resistance in Mycoplasma pneumoniae by Azithromycin Exposure
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethical Aspects
2.2. Sample Collection
2.3. Strains
2.4. Laboratory Tests and Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Strain No. | Isolation Date | Mutations | MICs of AZM (μg/mL) | P1 Type |
---|---|---|---|---|
FH (standard strains) | - | - | 0.001 | 2 |
M1601 | Jul-2019 | - | 0.0005 | 2 |
M1603 | Aug-2019 | - | 0.001 | 2g2 |
M1611 | Nov-2019 | - | 0.001 | 2g2 |
M1613 | Nov-2019 | - | 0.001 | 2g2 |
M1634 | Jun-2020 | - | 0.00012 | 2g2 |
M1644 | Sep-2020 | - | 0.0005 | 2g2 |
Strain No. | Maximal Concentrations (Strains Grew) | Mutations | Original MICs of AZM (μg/mL) |
---|---|---|---|
FH (standard strains) | No growth | Not possible | 0.001 |
M1601 | 0.004 | C2617G | 0.0005 |
M1603 | 0.004 | - | 0.001 |
M1611 | 0.004 | - | 0.001 |
M1613 | 0.004 | C2617A | 0.001 |
M1634 | No growth | Not possible | 0.00012 |
M1644 | No growth | Not possible | 0.0005 |
Strain No. | Maximal Concentrations (Strains Grew) | Mutations | Last Mutations |
---|---|---|---|
M1601 | 128 | A2063G | C2617G |
M1603 | No growth | Not possible | - |
M1611 | No growth | Not possible | - |
M1613 | 16 | C2617A | C2617A |
Strain No. | MICs of AZM (μg/mL) | Mutations | Original MIC (μg/mL) |
---|---|---|---|
M1601 | 128 | A2063G | 0.0005 |
M1613 | 0.0156 | C2617A | 0.001 |
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Oishi, T.; Hattori, N.; Yoshioka, D. Novel Knowledge of Macrolide Resistance in Mycoplasma pneumoniae by Azithromycin Exposure. Microorganisms 2024, 12, 218. https://doi.org/10.3390/microorganisms12010218
Oishi T, Hattori N, Yoshioka D. Novel Knowledge of Macrolide Resistance in Mycoplasma pneumoniae by Azithromycin Exposure. Microorganisms. 2024; 12(1):218. https://doi.org/10.3390/microorganisms12010218
Chicago/Turabian StyleOishi, Tomohiro, Nemu Hattori, and Daisuke Yoshioka. 2024. "Novel Knowledge of Macrolide Resistance in Mycoplasma pneumoniae by Azithromycin Exposure" Microorganisms 12, no. 1: 218. https://doi.org/10.3390/microorganisms12010218