Gastrointestinal Pathogens in Multi-Infected Individuals: A Cluster Analysis of Interaction
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethical Approval
2.2. Laboratory Techniques
2.3. Statistical Methods
2.4. Descriptive Analysis
2.5. Inferential Analysis
2.6. Datasets
- Dataset I
- Dataset II
3. Results
Differences between Datasets
- Dataset I
- Dataset II
- Exploratory moderated regression to scrutinize the interplay of the clusters
4. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Dataset | ||||
---|---|---|---|---|
N = 244 | 1 (Kogui) n = 150 | 2 (Wiwa) n = 94 | Both | Differ Significantly? |
Age M (SD) | 23.35 (18.59) | 21.01 (14.48) | 22.45 (17.13) | No t (230.7) = 1.1, p = 0.27 |
Persons infected with at least one pathogen | ||||
helminths n (%column) | 35 (23%) | 14 (15%) | 49 (20%) | No X2 (1, N = 244) = 2.07, p = 0.15 |
protozoa n (%column) | 138 (92%) | 93 (99%) | 231 (95%) | Yes X2 (1, N = 244) = 4.22, p = 0.04 |
bacteria n (%column) | 83 (55%) | 34 (36%) | 117 (48%) | Yes X2 (1, N = 244) = 7.75, p = 0.005 |
Average infections per person (M, SD) | ||||
helminths n (%column) | 0.28 (0.56) | 0.15 (0.36) | 0.23 (0.49) | Yes t (241.83) = 2.24, p = 0.026 |
protozoa n (%column) | 1.53 (0.73) | 1.77 (0.72) | 1.62 (0.74) | Yes t (198.7) = −2.50, p = 0.013 |
bacteria n (%column) | 0.62 (0.62) | 0.40 (0.57) | 0.54 (0.61) | Yes t (209.07) = 2.77, p = 0.006 |
Maximum number of infections in one person | ||||
helminths n (occurrence) | 3.00 (1) | 1.00 (14) | 3.00 (1) | |
protozoa n (occurrence) | 3.00 (9) | 4.00 (1) [3 pathogens found 12 times] | 4.00 (1) | |
bacteria n (occurrence) | 3.00 (1) | 2.00 (4) | 3.00 (1) | |
Number of pathogens | ||||
helminths n (%column) | 42 (28%) | 14 (15%) | 54 (22%) | |
protozoa n (%column) | 229 (152%) | 166 (176%) | 395 (161%) | |
bacteria n (%column) | 93 (62%) | 38 (40%) | 131 (54%) |
1 (Kogui) n = 150 | 2 (Wiwa) n = 94 | ||
---|---|---|---|
Microsporidia | Encephalitozoon spp. | 0 | 7 |
Helminths | Strongyloides spp. | 2 | 0 |
Hymenolepis spp. | 11 | 3 | |
Ascaris spp. | 12 | 0 | |
Taenia spp. | 4 | 1 | |
Trichuris trichiura | 9 | 0 | |
Necator americanus | 4 | 3 | |
Protozoa | Blastocystis hominis | 132 | 90 |
Giardia lamblia | 55 | 59 | |
Dientamoeba fragilis | 41 | 15 | |
Entamoeba histolytica | 0 | 1 | |
Cryptosporidium spp. | 1 | 1 | |
Bacteria | Shigella spp./EIEC | 11 | 7 |
Campylobacter spp. | 78 | 29 | |
Aeromonas spp. | 4 | 1 | |
Salmonella spp. | 0 | 1 |
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Backhaus, J.; Frickmann, H.; Hagen, R.M.; Concha, G.; Molitor, E.; Hoerauf, A.; Kann, S. Gastrointestinal Pathogens in Multi-Infected Individuals: A Cluster Analysis of Interaction. Microorganisms 2023, 11, 2642. https://doi.org/10.3390/microorganisms11112642
Backhaus J, Frickmann H, Hagen RM, Concha G, Molitor E, Hoerauf A, Kann S. Gastrointestinal Pathogens in Multi-Infected Individuals: A Cluster Analysis of Interaction. Microorganisms. 2023; 11(11):2642. https://doi.org/10.3390/microorganisms11112642
Chicago/Turabian StyleBackhaus, Joy, Hagen Frickmann, Ralf Matthias Hagen, Gustavo Concha, Ernst Molitor, Achim Hoerauf, and Simone Kann. 2023. "Gastrointestinal Pathogens in Multi-Infected Individuals: A Cluster Analysis of Interaction" Microorganisms 11, no. 11: 2642. https://doi.org/10.3390/microorganisms11112642